Publication:
Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.

dc.contributor.authorMeca-Lallana, José E
dc.contributor.authorMaurino, Jorge
dc.contributor.authorPérez-Miralles, Francisco
dc.contributor.authorForero, Lucía
dc.contributor.authorSepúlveda, María
dc.contributor.authorCalles, Carmen
dc.contributor.authorMartínez-Ginés, María L
dc.contributor.authorGonzález-Suárez, Inés
dc.contributor.authorBoyero, Sabas
dc.contributor.authorRomero-Pinel, Lucía
dc.contributor.authorSempere, Ángel P
dc.contributor.authorMeca-Lallana, Virginia
dc.contributor.authorQuerol, Luis
dc.contributor.authorCosta-Frossard, Lucienne
dc.contributor.authorPrefasi, Daniel
dc.contributor.authorGómez-Ballesteros, Rocío
dc.contributor.authorBallesteros, Javier
dc.date.accessioned2023-02-09T11:44:41Z
dc.date.available2023-02-09T11:44:41Z
dc.date.issued2021-07-29
dc.description.abstractThe assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire for measuring symptom severity in different domains affected by multiple sclerosis (MS), but has not been thoroughly evaluated in NMOSD. The aim of this study was to assess the psychometric properties of the SyMS in a sample of patients with NMOSD. A non-interventional, cross-sectional study in adult subjects with NMOSD (Wingerchuk 2015 criteria) was conducted at 13 neuroimmunology clinics applying the SyMS. A non-parametric item response theory procedure, Mokken analysis, was performed to assess the underlying dimensional structure and scalability of items and overall questionnaire. All analyses were performed with R (v4.0.3) using the mokken library. A total of 70 patients were studied (mean age: 47.5 ± 15 years, 80% female, mean Expanded Disability Status Scale score: 3.0 [interquartile range 1.5, 4.5]). Symptom severity was low (median SyMS score: 19.0 [interquartile range 10.0, 32.0]). The SyMS showed a robust internal reliability (Cronbach's alpha: 0.90 [95% confidence interval 0.86, 0.93]) and behaved as a unidimensional scale with all items showing scalability coefficients > 0.30. The overall SyMS scalability was 0.45 conforming to a medium scale according to Mokken's criteria. Fatigue and body pain were the domains with the highest scalability coefficients. The SyMS was associated with disability (rho: 0.586), and physical and psychological quality of life (rho: 0.856 and 0.696, respectively). The SyMS shows appropriate psychometric characteristics and may constitute a valuable and easy-to-implement option to measure symptom severity in patients with NMOSD.
dc.identifier.doi10.1371/journal.pone.0255317
dc.identifier.essn1932-6203
dc.identifier.pmcPMC8320986
dc.identifier.pmid34324586
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320986/pdf
dc.identifier.unpaywallURLhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0255317&type=printable
dc.identifier.urihttp://hdl.handle.net/10668/18275
dc.issue.number7
dc.journal.titlePloS one
dc.journal.titleabbreviationPLoS One
dc.language.isoen
dc.organizationHospital Universitario Puerta del Mar
dc.page.numbere0255317
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAdult
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeuromyelitis Optica
dc.subject.meshPsychometrics
dc.subject.meshQuality of Life
dc.subject.meshReproducibility of Results
dc.titleQuantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number16
dspace.entity.typePublication

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