Publication:
Cellular senescence or stemness: hypoxia flips the coin.

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Date

2021-07-29

Authors

Otero-Albiol, Daniel
Carnero, Amancio

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BioMed Central Ltd.
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Abstract

Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological functions beyond being a putative tumor suppressive trait. It remains unknown whether low levels of oxygen or hypoxia, which is a feature of every tissue in the organism, modulate cellular senescence, altering its capacity to suppress the limitation of proliferation. It has been observed that the lifespan of mammalian primary cells is increased under low oxygen conditions. Additionally, hypoxia promotes self-renewal and pluripotency maintenance in adult and embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and cancer stem cells (CSCs). In this study, we discuss the role of hypoxia facilitating senescence bypass during malignant transformation and acquisition of stemness properties, which all contribute to tumor development and cancer disease aggressiveness.

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MeSH Terms

Cell Differentiation
Cell Hypoxia
Cellular Senescence
Humans

DeCS Terms

Neoplasias
Senescencia celular
Hipoxia
Células
Oxígeno
Enfermedad
Longevidad
Células madre pluripotentes inducidas
Células Madre neoplásicas

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Keywords

cancer, cellular senescence, dedifferentiation, hypoxia, immortalization, oxygen, stemness

Citation

Otero-Albiol D, Carnero A. Cellular senescence or stemness: hypoxia flips the coin. J Exp Clin Cancer Res. 2021 Jul 29;40(1):243.