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Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.

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dc.contributor.authorRodríguez-Martínez, JM
dc.contributor.authorVelasco, C
dc.contributor.authorGarcía, I
dc.contributor.authorCano, ME
dc.contributor.authorMartínez-Martínez, L
dc.contributor.authorPascual, A
dc.contributor.authoraffiliation[Rodríguez-Martínez,JM;Velasco,C;García,L;Pascual ,A]Department of Microbiology, University of Seville, Seville.[Cano,ME]Service of Microbiology, University Hospital Marqués de Valdecilla, Santander, Spain.[Pascual,A] Service of Microbiology, University Hospital Virgen Macarena, Sevillees
dc.contributor.funderThis study was supported by the Dirección General de Investigación del Ministerio de Ciencia y Tecnología of Spain (project SAF2005-04704), the Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (project PI060580), and the Spanish Network for the Research in Infectious Diseases (REIPI RD06/0008) of Spain. This study was partially supported by a grant from Bayer.
dc.date.accessioned2012-07-26T08:26:00Z
dc.date.available2012-07-26T08:26:00Z
dc.date.issued2007-06
dc.description.abstractLa influencia de qnrA1 en el desarrollo de resistencia a quinolonas en enterobacterias se evaluó mediante el parámetro prevención concentración mutante. La expresión de qnrA1 aumentado considerablemente la concentración preventiva de mutantes en comparación con las cepas que no tienen este gen. En presencia de qnrA1, las mutaciones en los genes gyrA y parC se seleccionaron fácilmente para producir altos niveles de resistencia a quinolonases_ES
dc.description.abstractThe influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.es_ES
dc.description.versionYeses
dc.identifier.citationRodríguez-Martínez JM, Velasco C, García I,Cano ME, Martínez-Martínez L, Pascual A.Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.Antimicrob Agents Chemother. 2007 Jun;51(6):2236-9.es
dc.identifier.doi10.1128/AAC.01444-06
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/10668/425
dc.journal.titleAntimicrobial Agents and Chemotherapy
dc.language.isoen
dc.publisherAmerican Society for Microbiologyes
dc.relation.publisherversionhttp://aac.asm.org/content/51/6/2236.abstractes
dc.rights.accessRightsrestricted access
dc.subjectMutantes
dc.subjectpreventiones
dc.subjectfluoroquinoloneses
dc.subjectEnterobacteriaceaees
dc.subjectquinolone resistancees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agentses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteinses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Microbiological Techniques::Colony Count, Microbiales
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial::Drug Resistance, Bacteriales
dc.subject.meshMedical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceaees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteins::Escherichia coli Proteinses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinoloneses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Testses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Plasmids::Bacteriocin Plasmidses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agentses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteinses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteins::Escherichia coli Proteinses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinoloneses
dc.subject.meshMedical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Klebsiella::Klebsiella pneumoniaees
dc.titleMutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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