Publication: Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population.
dc.contributor.author | Cobos-Palacios, Lidia | |
dc.contributor.author | Ruiz-Moreno, Maria Isabel | |
dc.contributor.author | Vilches-Perez, Alberto | |
dc.contributor.author | Vargas-Candela, Antonio | |
dc.contributor.author | Muñoz-Ubeda, Monica | |
dc.contributor.author | Benitez Porres, Javier | |
dc.contributor.author | Navarro-Sanz, Ana | |
dc.contributor.author | Lopez-Carmona, Maria Dolores | |
dc.contributor.author | Sanz-Canovas, Jaime | |
dc.contributor.author | Perez-Belmonte, Luis M | |
dc.contributor.author | Mancebo-Sevilla, Juan Jose | |
dc.contributor.author | Gómez-Huelgas, Ricardo | |
dc.contributor.author | Bernal-Lopez, Maria Rosa | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fondo Europeo de Desarrollo Regional-FEDER | |
dc.contributor.funder | Consejería Salud, Junta de Andalucía | |
dc.date.accessioned | 2023-05-03T13:36:34Z | |
dc.date.available | 2023-05-03T13:36:34Z | |
dc.date.issued | 2022-06-09 | |
dc.description.abstract | Obesity is linked to elevated levels of inflammatory serum markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNFa). Adiponectin and resistin are adipokines related to obesity. It has been described that adipose tissue presents a high production and secretion of these diverse pro-inflammatory molecules, which may have local effects on the physiology of fat cells as well as systemic effects on other organs. Our aim was to evaluate the impact that lifestyle modifications, by following a Mediterranean Diet (MedDiet) program and physical activity (PA) training, would have on inflammatory biomarkers and adipokine profile in a Metabolically Healthy Obese (MHO) elderly population from Malaga (Andalusia, Spain). Subjects aged ≥65 years (65 to 87 years old) with obesity (BMI ≥30 kg/m2) were included in this study if they met ≤1 of the following criteria: systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥ 85 mmHg; triglycerides ≥150 mg/dL; HDL-C 166 MHO elderly subjects, 40 (24.1%) male and 126 (75.9%) female (p Healthy aging is a multifactorial biological process in which lifestyle is essential. The presence of obesity in elderly metabolically healthy population is not a problem necessarily. Elderly MHO population who eat a MedDiet and practice regularly PA are capable to modulate their production of inflammatory cytokines (CRP, IL-6, TNFa) and adipokines profile (adiponectin, resistin), preventing other metabolic disorders. | |
dc.description.version | Si | |
dc.identifier.citation | Cobos-Palacios L, Ruiz-Moreno MI, Vilches-Perez A, Vargas-Candela A, Muñoz-Úbeda M, Benítez Porres J, et al. Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population. PLoS One. 2022 Jun 9;17(6):e0265362 | |
dc.identifier.doi | 10.1371/journal.pone.0265362 | |
dc.identifier.essn | 1932-6203 | |
dc.identifier.pmc | PMC9182320 | |
dc.identifier.pmid | 35679338 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182320/pdf | |
dc.identifier.unpaywallURL | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0265362&type=printable | |
dc.identifier.uri | http://hdl.handle.net/10668/20423 | |
dc.issue.number | 6 | |
dc.journal.title | PloS one | |
dc.journal.titleabbreviation | PLoS One | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Virgen de la Victoria | |
dc.organization | Hospital Universitario Regional de Málaga | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.page.number | 13 | |
dc.provenance | Realizada la curación de contenido 16/04/2025 | |
dc.publisher | Public Library of Science | |
dc.pubmedtype | Journal Article | |
dc.pubmedtype | Research Support, Non-U.S. Gov't | |
dc.relation.projectID | PI18/ 00766 | |
dc.relation.projectID | CB06/03/0018 | |
dc.relation.projectID | CPII/00014 | |
dc.relation.projectID | C1-0005-2020 | |
dc.relation.projectID | RH-0100-2020 | |
dc.relation.publisherversion | https://dx.plos.org/10.1371/journal.pone.0265362 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adipokines | |
dc.subject | Adiponectin | |
dc.subject | Aged, 80 and over | |
dc.subject | Biomarkers | |
dc.subject | C-Reactive Protein | |
dc.subject.decs | Obesidad | |
dc.subject.decs | Interleucina-6 | |
dc.subject.decs | Adipoquinas | |
dc.subject.decs | Presión sanguínea | |
dc.subject.decs | Envejecimiento saludable | |
dc.subject.decs | Triglicéridos | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Insulins | |
dc.subject.mesh | Interleukin-6 | |
dc.subject.mesh | Male | |
dc.subject.mesh | Obesity | |
dc.subject.mesh | Obesity, Metabolically Benign | |
dc.subject.mesh | Resistin | |
dc.subject.mesh | Triglycerides | |
dc.subject.mesh | Tumor Necrosis Factor-alpha | |
dc.title | Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 17 | |
dspace.entity.type | Publication |