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Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer

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dc.contributor.authorJimenez-Luna, Cristina
dc.contributor.authorGonzález-Flores, Encarnación
dc.contributor.authorOrtiz, Raul
dc.contributor.authorMartínez-González, Luis J.
dc.contributor.authorAntúnez-Rodríguez, Alba
dc.contributor.authorExpósito-Ruiz, Manuela
dc.contributor.authorMelguizo, Consolación
dc.contributor.authorCaba, Octavio
dc.contributor.authorPrados, Jose
dc.contributor.authoraffiliation[Jimenez-Luna,C; Ortiz,R; Melguizo,C; Caba,O; Prados,J] Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, Granada, Spain. [Jimenez-Luna,C; Ortiz,R; Melguizo,C; Caba,O; Prados,J] Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain. [Jimenez-Luna,C; González-Flores,E; Ortiz,R; Melguizo,C; Caba,O; Prados,J] Instituto de Investigación Biosanitaria ibs. Granada, Granada, Spain. [González-Flores,E] Medical Oncology Service, Hospital Virgen de las Nieves, Granada, Spain. [Martínez-González,LJ; Antúnez-Rodríguez,A] GENyO, Centre for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain. [Expósito-Ruiz,M] Unit of Biostatistics, Department of Statistics and Operations Research, School of Medicine, University of Granada, Granada, Spain.
dc.contributor.funderThis work was partially supported by a grant from the Instituto de Salud Carlos III (ISCIII) (Project PI19/01478) (FEDER) and by the CTS-107 Group.
dc.date.accessioned2022-09-22T07:07:06Z
dc.date.available2022-09-22T07:07:06Z
dc.date.issued2021-05-22
dc.description.abstractGenes involved in the angiogenic process have been proposed for the diagnosis and therapeutic response of metastatic colorectal cancer (CRC). This study aimed to investigate the value of PTGS2, JAG1, GUCY2C and PGF-circulating RNA as biomarkers in metastatic CRC. Blood cells and serum mRNA from 59 patients with metastatic CRC and 47 healthy controls were analyzed by digital PCR. The area under the receiver operating characteristic curve (AUC) was used to estimate the diagnostic value of each mRNA alone or mRNA combinations. A significant upregulation of the JAG1, PTGS2 and GUCY2C genes in blood cells and serum samples from metastatic CRC patients was detected. Circulating mRNA levels in the serum of all genes were significantly more abundant than in blood. The highest discrimination ability between metastatic CRC patients and healthy donors was obtained with PTGS2 (AUC of 0.984) and GUCY2C (AUC of 0.896) in serum samples. Biomarker combinations did not improve the discriminatory capacity of biomarkers separately. Analyzed biomarkers showed no correlation with overall survival or progression-free survival, but GUCY2C and GUCY2C/PTGS2 expression in serum correlated significantly with the response to antiangiogenic agents. These findings demonstrate that assessment of genes involved in the angiogenic process may be a potential non-invasive diagnostic tool for metastatic CRC and its response to antiangiogenic therapy.es_ES
dc.description.versionYeses_ES
dc.identifier.citationJimenez-Luna C, González-Flores E, Ortiz R, Martínez-González LJ, Antúnez-Rodríguez A, Expósito-Ruiz M, et al. Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer. J Clin Med. 2021 May 22;10(11):2248es_ES
dc.identifier.doi10.3390/jcm10112248es_ES
dc.identifier.essn2077-0383
dc.identifier.pmcPMC8196898
dc.identifier.pmid34067294es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4100
dc.journal.titleJournal of Clinical Medicine
dc.language.isoen
dc.page.number16 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/10/11/2248/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMetastatic colon canceres_ES
dc.subjectBiomarkerses_ES
dc.subjectAngiogenesises_ES
dc.subjectLiquid biopsyes_ES
dc.subjectCirculating mRNAes_ES
dc.subjectDigital PCRes_ES
dc.subjectMetástasis de la neoplasiaes_ES
dc.subjectNeoplasias del colones_ES
dc.subjectBiomarcadoreses_ES
dc.subjectBiopsia líquidaes_ES
dc.subjectARN mensajeroes_ES
dc.subjectReacción en cadena de la polimerasaes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Multienzyme Complexes::Prostaglandin-Endoperoxide Synthases::Cyclooxygenase 2es_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Angiogenesis Modulating Agents::Angiogenesis Inhibitorses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Area Under Curvees_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::ROC Curvees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Up-Regulationes_ES
dc.subject.meshMedical Subject Headings::Diseases::Digestive System Diseases::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messengeres_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Blood Cellses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reactiones_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Inflammation Mediators::Autacoids::Eicosanoids::Prostaglandins::Prostaglandins Fes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markerses_ES
dc.titleCirculating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Canceres_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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