Publication:
Defining the Role of Monocytes in Sjögren's Syndrome.

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Date

2022-10-20

Authors

Sequi-Sabater, Jose Miguel
Beretta, Lorenzo

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MDPI
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Abstract

Sjögren's syndrome is one of the most prevalent autoimmune diseases after rheumatoid arthritis, with a preference for middle age, and is characterised by exocrine glandular involvement leading to xerostomia and xerophthalmia. It can have systemic implications with vascular, neurological, renal, and pulmonary involvement, and in some cases, it may evolve to non-Hodgkin's lymphoma. For a long time, B- and T-lymphocytes have been the focus of research and have been considered key players in Sjögren's syndrome pathogenesis and evolution. With the development of new technologies, including omics, more insights have been found on the different signalling pathways that lead to inflammation and activation of the immune system. New evidence indicates that a third actor linking innate and adaptive immunity plays a leading role in the Sjögren's syndrome play: the monocyte. This review summarises the recent insights from transcriptomic, proteomic, and epigenetic studies that help us to understand more about the Sjögren's syndrome pathophysiology and redefine the involvement of monocytes in this disease.

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MeSH Terms

Middle aged
Humans
Sjogren's syndrome
Monocytes
Proteomics
Xerostomia
Xerophthalmia

DeCS Terms

Monocitos
Persona de mediana edad
Proteómica
Síndrome de Sjögren
Xeroftalmia
Xerostomía

CIE Terms

Keywords

RNA sequencing, Epigenetics, Inflammation, Monocytes

Citation

Sequí-Sabater JM, Beretta L. Defining the Role of Monocytes in Sjögren's Syndrome. Int J Mol Sci. 2022 Oct 23;23(21):12765