Publication: Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
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Identifiers
Date
2017-10-09
Authors
Batllori, Marta
Molero-Luis, Marta
Arrabal, Luisa
Heras, Javier de Las
Fernandez-Ramos, Joaquin-Alejandro
Gutierrez-Solana, Luis Gonzalez
Ibañez-Mico, Salvador
Domingo, Rosario
Campistol, Jaume
Ormazabal, Aida
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Melatonin is synthesized from serotonin and it is excreted as sulphatoxymelatonin in urine. We aim to evaluate urinary sulphatoxymelatonin as a biomarker of brain serotonin status in a cohort of patients with mutations in genes related to serotonin biosynthesis. We analized urinary sulphatoxymelatonin from 65 healthy subjects and from 28 patients with genetic defects. A total of 18 patients were studied: 14 with autosomal dominant and recessive guanosine triphosphate cyclohydrolase-I deficiency; 3 with sepiapterin reductase deficiency; and 1 with aromatic L-amino acid decarboxylase deficiency. Further 11 patients were studied after receiving serotoninergic treatment (serotonin precursors, monoamine oxidase inhibitors, selective serotonin re-uptake inhibitors): 5 with aromatic L-amino acid decarboxylase deficiency; 1 with sepiapterin reductase deficiency; 3 with dihydropteridine reductase deficiency; and 2 with 6-pyruvoyltetrahydropterin synthase deficiency. Among the patients without therapy, 6 presented low urinary sulphatoxymelatonin values, while most of the patients with guanosine triphosphate cyclohydrolase-I deficiency showed normal values. 5 of 11 patients under treatment presented low urine sulphatoxymelatonin values. Thus, decreased excretion of sulphatoxymelatonin is frequently observed in cases with severe genetic disorders affecting serotonin biosynthesis. In conclusion, sulphatoxymelatonin can be a good biomarker to estimate serotonin status in the brain, especially for treatment monitoring purposes.
Description
MeSH Terms
Adolescent
Adult
Biogenic amines
Biomarkers
Child
Child, preschool
Female
Humans
Male
Melatonin
Metabolic networks and pathways
Adult
Biogenic amines
Biomarkers
Child
Child, preschool
Female
Humans
Male
Melatonin
Metabolic networks and pathways
DeCS Terms
Aminas biogénicas
Biomarcadores
Melatonina
Niño
Preescolar
Redes y vías metabólicas
Biomarcadores
Melatonina
Niño
Preescolar
Redes y vías metabólicas
CIE Terms
Keywords
Metabolism, inborn errors, Middle aged, Reference values, Serotonin, Young adult
Citation
Batllori M, Molero-Luis M, Arrabal L, Heras JL, Fernandez-Ramos JA, Gutiérrez-Solana LG, et al. Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients. Sci Rep. 2017 Nov 7;7(1):14675