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Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.

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Date

2017-10-09

Authors

Batllori, Marta
Molero-Luis, Marta
Arrabal, Luisa
Heras, Javier de Las
Fernandez-Ramos, Joaquin-Alejandro
Gutierrez-Solana, Luis Gonzalez
Ibañez-Mico, Salvador
Domingo, Rosario
Campistol, Jaume
Ormazabal, Aida

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Nature Publishing Group
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Abstract

Melatonin is synthesized from serotonin and it is excreted as sulphatoxymelatonin in urine. We aim to evaluate urinary sulphatoxymelatonin as a biomarker of brain serotonin status in a cohort of patients with mutations in genes related to serotonin biosynthesis. We analized urinary sulphatoxymelatonin from 65 healthy subjects and from 28 patients with genetic defects. A total of 18 patients were studied: 14 with autosomal dominant and recessive guanosine triphosphate cyclohydrolase-I deficiency; 3 with sepiapterin reductase deficiency; and 1 with aromatic L-amino acid decarboxylase deficiency. Further 11 patients were studied after receiving serotoninergic treatment (serotonin precursors, monoamine oxidase inhibitors, selective serotonin re-uptake inhibitors): 5 with aromatic L-amino acid decarboxylase deficiency; 1 with sepiapterin reductase deficiency; 3 with dihydropteridine reductase deficiency; and 2 with 6-pyruvoyltetrahydropterin synthase deficiency. Among the patients without therapy, 6 presented low urinary sulphatoxymelatonin values, while most of the patients with guanosine triphosphate cyclohydrolase-I deficiency showed normal values. 5 of 11 patients under treatment presented low urine sulphatoxymelatonin values. Thus, decreased excretion of sulphatoxymelatonin is frequently observed in cases with severe genetic disorders affecting serotonin biosynthesis. In conclusion, sulphatoxymelatonin can be a good biomarker to estimate serotonin status in the brain, especially for treatment monitoring purposes.

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MeSH Terms

Adolescent
Adult
Biogenic amines
Biomarkers
Child
Child, preschool
Female
Humans
Male
Melatonin
Metabolic networks and pathways

DeCS Terms

Aminas biogénicas
Biomarcadores
Melatonina
Niño
Preescolar
Redes y vías metabólicas

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Keywords

Metabolism, inborn errors, Middle aged, Reference values, Serotonin, Young adult

Citation

Batllori M, Molero-Luis M, Arrabal L, Heras JL, Fernandez-Ramos JA, Gutiérrez-Solana LG, et al. Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients. Sci Rep. 2017 Nov 7;7(1):14675