Publication:
Clinical status, quality of life, and work productivity in Crohn's disease patients after one year of treatment with adalimumab.

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Date

2016-10-22

Authors

Saro, Cristina
Ceballos, Daniel
Muñoz, Fernando
de la Coba, Cristóbal
Aguilar, Maria Dolores
Lazaro, Pablo
Garcia-Sanchez, Valle
Hernandez, Mariola
Barrio, Jesus
de Francisco, Ruth

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Sociedad Española de Patologia Digestiva
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Abstract

Clinical trials have shown the efficacy of adalimumab in Crohn's disease, but the outcome in regular practice remains unknown. The aim of the study was to examine clinical status, quality of life, and work productivity of Crohn's disease patients receiving adalimumab for one year in the context of usual clinical practice. This was a prospective, observational study with a one-year follow-up. After baseline, Crohn's disease patients were evaluated at 1, 3, 6, 9, and 12 months after starting treatment with adalimumab. Outcome variables included: clinical status (measured with CDAI), quality of life (measured with EuroQoL-5D and IBDQ), and work productivity (measured with WPAI questionnaire). These outcome variables were compared using the Student's t test or Wilcoxon test for paired comparison data according to the data distribution. Statistical significance was set at two-sided p The sample was composed of 126 patients (age [mean] 39.1 ± [standard deviation] 13.8 years; 51% male). Significant changes were observed during the follow-up period: CDAI decreased from [median] 194 ([25-75 percentiles] 121-269) to 48.2 (10.1-122.0) (p In regular practice, adalimumab is clinically effective in the treatment of Crohn's disease patients and results in a significant improvement in quality of life and work productivity.

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MeSH Terms

Adalimumab
Adult
Aged
Crohn disease
Efficiency
Female
Follow-up studies
Humans
Immunosuppressive agents
Male
Middle aged
Prospective studies
Quality of life
Treatment outcome
Work
Young adult

DeCS Terms

Calidad de vida
Eficiencia
Enfermedad de Crohn
Inmunosupresores
Resultado del tratamiento
Trabajo

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Citation

Saro C, Ceballos D, Muñoz F, de la Coba C, Aguilar MD, Lázaro P, et al. Clinical status, quality of life, and work productivity in Crohn's disease patients after one year of treatment with adalimumab. Rev Esp Enferm Dig. 2017 Feb;109(2):122-129