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Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study.

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dc.contributor.authorMariosa, Daniela
dc.contributor.authorSmith-Byrne, Karl
dc.contributor.authorRichardson, Tom G
dc.contributor.authorFerrari, Pietro
dc.contributor.authorGunter, Marc J
dc.contributor.authorPapadimitriou, Nikos
dc.contributor.authorMurphy, Neil
dc.contributor.authorChristakoudi, Sofia
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorRiboli, Elio
dc.contributor.authorMuller, David
dc.contributor.authorPurdue, Mark P
dc.contributor.authorChanock, Stephen J
dc.contributor.authorHung, Rayjean J
dc.contributor.authorAmos, Christopher I
dc.contributor.authorO'Mara, Tracy A
dc.contributor.authorAmiano, Pilar
dc.contributor.authorPasanisi, Fabrizio
dc.contributor.authorRodriguez-Barranco, Miguel
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHalkjær, Jytte
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorSkeie, Guri
dc.contributor.authorRylander, Charlotta
dc.contributor.authorBorch, Kristin Benjaminsen
dc.contributor.authorAune, Dagfinn
dc.contributor.authorHeath, Alicia K
dc.contributor.authorWard, Heather A
dc.contributor.authorSchulze, Matthias
dc.contributor.authorBonet, Catalina
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorDavey Smith, George
dc.contributor.authorBrennan, Paul
dc.contributor.authorJohansson, Mattias
dc.contributor.funderEuropean Research Council
dc.contributor.funderMedical Research Council of Australia
dc.contributor.funderRegional Governments of Andalucıa, Asturias, Basque Country, Murcia, Navarra
dc.contributor.funderHealth Research Fund (FISISCIII)
dc.contributor.funderEuropean Commission (DG-SANCO)
dc.contributor.funderWorld Cancer Research Fund International programme
dc.contributor.funderCatalan Institute of Oncology (Barcelona) (Spain)
dc.date.accessioned2023-05-03T13:27:41Z
dc.date.available2023-05-03T13:27:41Z
dc.date.issued2022-03-16
dc.description.abstractIt is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.
dc.description.versionSi
dc.identifier.citationMariosa D, Smith-Byrne K, Richardson TG, Ferrari P, Gunter MJ, Papadimitriou N, et al. Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study. J Natl Cancer Inst. 2022 Sep 9;114(9):1296-1300.
dc.identifier.doi10.1093/jnci/djac061
dc.identifier.essn1460-2105
dc.identifier.pmcPMC9468294
dc.identifier.pmid35438160
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468294/pdf
dc.identifier.unpaywallURLhttps://academic.oup.com/jnci/article-pdf/114/9/1296/45751642/djac061.pdf
dc.identifier.urihttp://hdl.handle.net/10668/19809
dc.issue.number9
dc.journal.titleJournal of the National Cancer Institute
dc.journal.titleabbreviationJ Natl Cancer Inst
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number1296-1300
dc.provenanceRealizada la curación de contenido 23/08/2024
dc.publisherOxford University Press
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDEU FP7
dc.relation.projectIDR01-CA134958
dc.relation.projectIDAPP1061779
dc.relation.projectIDAPP1111246
dc.relation.projectIDAPP1109286
dc.relation.projectIDAPP1031333
dc.relation.projectIDAPP552402
dc.relation.publisherversionhttps://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djac061
dc.rightsAttribution 3.0 Intergovernmental Organization.
dc.rights.accessRightsopen access
dc.rights.uri(https://creativecommons.org/licenses/by/3.0/igo/
dc.subjectobesity
dc.subjectbody mass index procedure
dc.subjectcancer
dc.subjectrenal cancer
dc.subjectattenuation
dc.subjectcancer risk
dc.subjectkidney
dc.subject.decsAdulto
dc.subject.decsAnálisis de la aleatorización Mendeliana
dc.subject.decsEstudio de asociación del genoma completo
dc.subject.decsEstudios prospectivos
dc.subject.decsEstudios de cohortes
dc.subject.decsHumanos
dc.subject.decsNeoplasias
dc.subject.decsObesidad
dc.subject.decsTamaño corporal
dc.subject.decsÍndice de masa corporal
dc.subject.meshAdult
dc.subject.meshBody Mass Index
dc.subject.meshBody Size
dc.subject.meshCohort Studies
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshMendelian Randomization Analysis
dc.subject.meshNeoplasms
dc.subject.meshObesity
dc.subject.meshProspective Studies
dc.titleBody Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number114
dspace.entity.typePublication

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