Publication: Baja densidad mineral ósea en artritis idiopática juvenil: prevalencia y factores relacionados.
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Identifiers
Date
2017-02-23
Authors
Galindo-Zavala, Rocio
Nuñez-Cuadros, Esmeralda
Martin-Pedraz, Laura
Diaz-Cordoves-Rego, Gisela
Sierra-Salinas, Carlos
Urda-Cardona, Antonio
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Introducción: Actualmente se recomienda ajustar por talla el Z-score de densidad mineral ósea obtenida mediante absorciometría de rayos X de doble energía en pediatría. No hay estudios en nuestro medio que evalúen la prevalencia de baja densidad mineral ósea para la edad cronológica (BDMOec) en niños con artritis idiopática juvenil (AIJ) siguiendo estas recomendaciones. Objetivos: Estimar la prevalencia de BDMOec en niños con AIJ en nuestro medio y evaluar los factores implicados en su desarrollo. Métodos: Estudio observacional, transversal, en niños caucásicos de 5-16 años con AIJ, en seguimiento por una unidad de reumatología pediátrica entre julio de 2014 y julio de 2015. Se recogieron datos antropométricos, clínicos y de tratamiento. Se realizaron absorciometrías de rayos X de doble energía, estudio metabólico óseo y encuestas sobre dieta y ejercicio. Resultados: Participaron 92 niños. La estimación de la prevalencia poblacional de BDMOec fue inferior al 5% (IC 95%). En el análisis multivariante, el porcentaje de índice de masa corporal (B: 0,021; p < 0,001) y el índice de masa magra (B: 0,0002; p = 0,012) presentaron relación positiva con el Z-score de DMO ajustado por talla, mientras que el índice de masa grasa (B: -0,0001; p = 0,018) y el propéptido aminoterminal del colágeno tipo I (B: -0,0006; p = 0,036) presentaron correlaciones negativas. Conclusiones: La prevalencia de BDMOec en los niños con AIJ en nuestro medio es baja. Un adecuado estado nutritivo y el predominio de la masa magra sobre la grasa podrían favorecer la adquisición de masa ósea. Aquellos pacientes con AIJ con DMO más baja podrían estar sometidos a un aumento del remodelado óseo
Height adjustment is currently recommended for Z-score bone mineral density (BMD) assessed by dual energy X-ray absorptiometry. At present there are no studies that evaluate the prevalence of low BMD in paediatric patients with Juvenile Idiopathic Arthritis (JIA) in Spain following current recommendations. To evaluate low BMD in JIA in paediatric patients with JIA in Spain following the latest recommendations, as well as to assess associated factors. Observational cross-sectional study of Spanish JIA patients from 5 to 16 years-old, followed-up in a Paediatric Rheumatology Unit between July 2014 and July 2015. Anthropometric, clinical and treatment data were recorded. Dual energy X-ray absorptiometry, and bone metabolism parameters were collected, and a completed diet and exercise questionnaire was obtained. A total of 92 children participated. The population prevalence estimation of low BMD was less than 5% (95% CI). A significant positive correlation was found in the multiple linear regression analysis between the body mass index percentile (B: 0.021; P Low BMD prevalence in JIA patients in our population is low. An adequate nutritional status and the prevalence of lean over fat mass seem to promote the acquisition of bone mass. Those JIA patients with lower BMD could be subjected to an increase of bone turnover.
Height adjustment is currently recommended for Z-score bone mineral density (BMD) assessed by dual energy X-ray absorptiometry. At present there are no studies that evaluate the prevalence of low BMD in paediatric patients with Juvenile Idiopathic Arthritis (JIA) in Spain following current recommendations. To evaluate low BMD in JIA in paediatric patients with JIA in Spain following the latest recommendations, as well as to assess associated factors. Observational cross-sectional study of Spanish JIA patients from 5 to 16 years-old, followed-up in a Paediatric Rheumatology Unit between July 2014 and July 2015. Anthropometric, clinical and treatment data were recorded. Dual energy X-ray absorptiometry, and bone metabolism parameters were collected, and a completed diet and exercise questionnaire was obtained. A total of 92 children participated. The population prevalence estimation of low BMD was less than 5% (95% CI). A significant positive correlation was found in the multiple linear regression analysis between the body mass index percentile (B: 0.021; P Low BMD prevalence in JIA patients in our population is low. An adequate nutritional status and the prevalence of lean over fat mass seem to promote the acquisition of bone mass. Those JIA patients with lower BMD could be subjected to an increase of bone turnover.
Description
MeSH Terms
Adolescent
Arthritis, Juvenile
Bone Density
Child
Cross-Sectional Studies
Female
Humans
Male
Osteoporosis
Prevalence
Arthritis, Juvenile
Bone Density
Child
Cross-Sectional Studies
Female
Humans
Male
Osteoporosis
Prevalence
DeCS Terms
Densidad ósea
Pediatría
Absorciometría de fotón
Análisis multivariante
Ejercicio físico
Artritis juvenil
Pediatría
Absorciometría de fotón
Análisis multivariante
Ejercicio físico
Artritis juvenil
CIE Terms
Keywords
Artritis idiopática juvenil, Baja densidad mineral ósea para la edad cronológica, Body composition, Bone mineral density, Composición corporal, Densidad mineral ósea, Estado nutricional, Juvenile idiopathic arthritis, Low bone mineral density for chronological age, Marcadores del metabolismo óseo, Nutritional status, bone turnover markers
Citation
Galindo Zavala R, Núñez Cuadros E, Martín Pedraz L, Díaz-Cordovés Rego G, Sierra Salinas C, Urda Cardona A. Baja densidad mineral ósea en artritis idiopática juvenil: prevalencia y factores relacionados [Low bone mineral density in juvenile idiopathic arthritis: Prevalence and related factors]. An Pediatr (Barc). 2017 Oct;87(4):218-225. Spanish