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Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review.

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dc.contributor.authorMartinez-Montoro, Jose Ignacio
dc.contributor.authorGarcia-Fontana, Beatriz
dc.contributor.authorGarcia-Fontana, Cristina
dc.contributor.authorMuñoz-Torres, Manuel
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderEuropean Regional Development Fund (FEDER)
dc.contributor.funderJunta de Andalucía
dc.date.accessioned2023-05-03T14:06:22Z
dc.date.available2023-05-03T14:06:22Z
dc.date.issued2022-04-13
dc.description.abstractBone fragility is a common complication in subjects with type 2 diabetes mellitus (T2DM). However, traditional techniques for the evaluation of bone fragility, such as dual-energy X-ray absorptiometry (DXA), do not perform well in this population. Moreover, the Fracture Risk Assessment Tool (FRAX) usually underestimates fracture risk in T2DM. Importantly, novel technologies for the assessment of one microarchitecture in patients with T2DM, such as the trabecular bone score (TBS), high-resolution peripheral quantitative computed tomography (HR-pQCT), and microindentation, are emerging. Furthermore, different serum and urine bone biomarkers may also be useful for the evaluation of bone quality in T2DM. Hence, in this article, we summarize the limitations of conventional tools for the evaluation of bone fragility and review the current evidence on novel approaches for the assessment of quality and bone microstructure alterations in patients with T2DM.
dc.description.versionSi
dc.identifier.citationMartínez-Montoro JI, García-Fontana B, García-Fontana C, Muñoz-Torres M. Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review. J Clin Med. 2022 Apr 14;11(8):2206.
dc.identifier.doi10.3390/jcm11082206
dc.identifier.issn2077-0383
dc.identifier.pmcPMC9024806
dc.identifier.pmid35456299
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024806/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2077-0383/11/8/2206/pdf?version=1650260878
dc.identifier.urihttp://hdl.handle.net/10668/21271
dc.issue.number8
dc.journal.titleJournal of clinical medicine
dc.journal.titleabbreviationJ Clin Med
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number14
dc.provenanceRealizada la curación de contenido 22/08/2024
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.relation.projectIDPI18–00803
dc.relation.projectIDPI21–01069
dc.relation.projectIDPI18–01235
dc.relation.projectIDPI-0268–2019
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=jcm11082206
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbone fragility
dc.subjectbone quality
dc.subjectbone structure
dc.subjectfracture risk
dc.subjecttype 2 diabetes mellitus
dc.subject.decsAbsorciometría de fotón
dc.subject.decsBiomarcadores
dc.subject.decsDiabetes Mellitus tipo 2
dc.subject.decsFracturas óseas
dc.subject.decsHueso esponjoso
dc.subject.decsHumanos
dc.subject.decsMedición de riesgo
dc.subject.decsTomografía
dc.subject.meshHumans
dc.subject.meshCancellous Bone
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshAbsorptiometry, Photon
dc.subject.meshFractures, Bone
dc.subject.meshRisk Assessment
dc.subject.meshBiomarkers
dc.subject.meshTomography
dc.titleEvaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication

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