Publication:
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Simple item page
dc.contributor.authorKared, Hassen
dc.contributor.authorTan, Shu Wen
dc.contributor.authorLau, Mai Chan
dc.contributor.authorChevrier, Marion
dc.contributor.authorTan, Crystal
dc.contributor.authorHow, Wilson
dc.contributor.authorWong, Glenn
dc.contributor.authorStrickland, Marie
dc.contributor.authorMalleret, Benoit
dc.contributor.authorAmoah, Amanda
dc.contributor.authorPilipow, Karolina
dc.contributor.authorZanon, Veronica
dc.contributor.authorGovern, Naomi Mc
dc.contributor.authorLum, Josephine
dc.contributor.authorChen, Jin Miao
dc.contributor.authorLee, Bernett
dc.contributor.authorFlorian, Maria Carolina
dc.contributor.authorGeiger, Hartmut
dc.contributor.authorGinhoux, Florent
dc.contributor.authorRuiz-Mateos, Ezequiel
dc.contributor.authorFulop, Tamas
dc.contributor.authorRajasuriar, Reena
dc.contributor.authorKamarulzaman, Adeeba
dc.contributor.authorNg, Tze Pin
dc.contributor.authorLugli, Enrico
dc.contributor.authorLarbi, Anis
dc.contributor.authoraffiliation[Kared,H; Tan,SW; Lau,MC; Chevrier,M; Tan,C; How,W, Wong,G; Strickland,M; Malleret,B; Govern,NM; Lum,J; Chen,JM; Lee,B; Ginhoux,F; Larbi,A] Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Republic of Singapore. [Strickland,M] Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. [Malleret,B; Larbi,A] Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. [Amoah,A; Florian,MC; Geiger,H] Institute of Molecular Medicine, University of Ulm, Ulm, Germany. [Pilipow,K; Zanon,V; Lugli,E] Humanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI), Rozzano, Italy. [Geiger,H] Experimental Hematology and Cancer Biology, CCHMC, Cincinnati, OH, USA. [Ruiz-Mateos,E] Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain. [Fulop.T; Larbi,A] Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada. [Rajasuriar,R; Kamarulzaman,A] Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia. [Rajasuriar,R] The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. [Rajasuriar,R; Kamarulzaman,A] Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. [Ng,TP] Gerontology Research Programme and Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
dc.contributor.funderThe study is supported by a research grant from the Agency for Science, Technology and Research (No. 10-036), by the Singapore Immunology Network and by a Starting Grant from the European Research Council (ERC-StG-2014 PERSYST 640511 to E.L.). A.L. is a scholar of International Society for Advancement of Cytometry (ISAC). R.R. and A.K. are funded by the High Impact Research/Ministry of Higher Education Research Grant, Malaysia (HIR/ MOHE; H-20001-E000001) and the RU grant (UMRG RP029-14HTM). E.R-M was supported by Consejería de Salud y Bienestar Social of Junta de Andalucía through the Nicolás Monardes Program (C-0032/17) and Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Fondos Europeos para el Desarrollo Regional, FEDER, grants PI16/ 00684, PI19/01127, RETICS, Red de Investigación en SIDA (RD16/0025/0020).
dc.date.accessioned2022-08-01T11:16:53Z
dc.date.available2022-08-01T11:16:53Z
dc.date.issued2020-02-10
dc.description.abstractThe diversity of the naïve T cell repertoire drives the replenishment potential and capacity of memory T cells to respond to immune challenges. Attrition of the immune system is associated with an increased prevalence of pathologies in aged individuals, but whether stem cell memory T lymphocytes (TSCM) contribute to such attrition is still unclear. Using single cells RNA sequencing and high-dimensional flow cytometry, we demonstrate that TSCM heterogeneity results from differential engagement of Wnt signaling. In humans, aging is associated with the coupled loss of Wnt/β-catenin signature in CD4 TSCM and systemic increase in the levels of Dickkopf-related protein 1, a natural inhibitor of the Wnt/β-catenin pathway. Functional assays support recent thymic emigrants as the precursors of CD4 TSCM. Our data thus hint that reversing TSCM defects by metabolic targeting of the Wnt/β-catenin pathway may be a viable approach to restore and preserve immune homeostasis in the context of immunological history.es_ES
dc.description.versionYeses_ES
dc.identifier.citationKared H, Tan SW, Lau MC, Chevrier M, Tan C, How W, et al. Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway. Nat Commun. 2020 Feb 10;11(1):821es_ES
dc.identifier.doi10.1038/s41467-020-14442-6es_ES
dc.identifier.essn2041-1723
dc.identifier.pmcPMC7010798
dc.identifier.pmid32041953es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3859
dc.journal.titleNature Communications
dc.language.isoen
dc.page.number17 p.
dc.publisherSpringer Naturees_ES
dc.relation.publisherversionhttps://www.nature.com/articles/s41467-020-14442-6es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMemory T cellses_ES
dc.subjectWnt signaling pathwayes_ES
dc.subjectFlow cytometryes_ES
dc.subjectImmune systemes_ES
dc.subjectCateninses_ES
dc.subjectCélulas T de memoriaes_ES
dc.subjectVía de señalización wntes_ES
dc.subjectCitometría de flujoes_ES
dc.subjectSistema inmunológicoes_ES
dc.subjectCateninases_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Aginges_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Antigenses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD4-Positive T-Lymphocyteses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profilinges_ES
dc.subject.meshMedical Subject Headings::Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infectionses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunologic Memoryes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteinses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Micees_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cells::Hematopoietic Stem Cells::Lymphoid Progenitor Cells::Precursor Cells, T-Lymphoides_ES
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Lymphoid Tissue::Thymus Glandes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction::Wnt Signaling Pathwayes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors::beta Catenines_ES
dc.titleImmunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathwayes_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 3 of 3
Thumbnail Image
Name:
Kared_ImmunologicalHistory.pdf
Size:
3.77 MB
Format:
Adobe Portable Document Format
Description:
Artículo publicado
Download
Thumbnail Image
Name:
Kared_ImmunologicalHistory_MaterialSuplementario1.pdf
Size:
18.8 MB
Format:
Adobe Portable Document Format
Description:
Material suplementario
Download
No Thumbnail Available
Name:
Kared_ImmunologicalHistory_MaterialSuplementario2.xlsx
Size:
19.23 KB
Format:
Microsoft Excel XML
Description:
Material suplementario
Download

Collections

Instituto de Investigación Biomédica de Sevilla (IBIS)
SAS - Hospital Universitario Virgen del Rocío

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía