Publication: Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.
Loading...
Identifiers
Date
2018-05-17
Authors
Gomez-Samblas, M
Bernal, D
Bolado-Ortiz, A
Vilchez, S
Bolás-Fernández, F
Espino, A M
Trelis, M
Osuna, A
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p
Description
MeSH Terms
Animals
Antibodies, Monoclonal
Injections, Intraperitoneal
Interleukin-23
Interleukins
Intestines
Male
Mice
Mice, Inbred ICR
Nematode Infections
Parasite Load
Antibodies, Monoclonal
Injections, Intraperitoneal
Interleukin-23
Interleukins
Intestines
Male
Mice
Mice, Inbred ICR
Nematode Infections
Parasite Load