Publication:
Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.

Loading...
Thumbnail Image

Date

2018-05-17

Authors

Gomez-Samblas, M
Bernal, D
Bolado-Ortiz, A
Vilchez, S
Bolás-Fernández, F
Espino, A M
Trelis, M
Osuna, A

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p 

Description

MeSH Terms

Animals
Antibodies, Monoclonal
Injections, Intraperitoneal
Interleukin-23
Interleukins
Intestines
Male
Mice
Mice, Inbred ICR
Nematode Infections
Parasite Load

DeCS Terms

CIE Terms

Keywords

Citation