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Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review).

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dc.contributor.authorMartino, Alessandro
dc.contributor.authorSainz, Juan
dc.contributor.authorBuda, Gabriele
dc.contributor.authorJamroziak, Krzysztof
dc.contributor.authorReis, Rui Manuel
dc.contributor.authorGarcía-Sanz, Ramón
dc.contributor.authorJurado, Manuel
dc.contributor.authorRíos, Rafael
dc.contributor.authorSzemraj-Rogucka, Zofia
dc.contributor.authorMarques, Herlander
dc.contributor.authorLesueur, Fabienne
dc.contributor.authorMoreno, Victor
dc.contributor.authorOrciuolo, Enrico
dc.contributor.authorGemignani, Federica
dc.contributor.authorLandi, Stefano
dc.contributor.authorRossi, Anna Maria
dc.contributor.authorDumontet, Charles
dc.contributor.authorPetrini, Mario
dc.contributor.authorCampa, Daniele
dc.contributor.authorCanzian, Federico
dc.contributor.authoraffiliation[Martino,A; Campa,D; Canzian,F] Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Sainz,J; Jurado,M; Ríos,R] Genomic Oncology Area, Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research (GENYO), Granada. Department of Hematology, Virgen de las Nieves University Hospital, Granada, Spain. [Buda,G; Orciuolo,E; Petrini,M] Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, University of Pisa, Pisa, Italy. [Jamroziak,K; Szemraj-Rogucka,Z] Department of Hematology, Medical University of Lodz, Lodz, Poland. [Reis,RM; Marques,H] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal. [García-Sanz,R] University Hospital of Salamanca, Universidad de Salamanca-Centro de Investigación del Cáncer, Salamanca, Spain. [Lesueur,F] Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France. [Moreno,V] IDIBELL-Catalan Institute of Oncology, CIBERESP and University of Barcelona, Barcelona, Spain. [Gemignani,F; Landi,S; Rossi,AM] Department of Biology, Section of Genetics, University of Pisa, Pisa, Italy. [Dumontet,C] INSERM UMR 1052/CNRS 5286, Laboratoire de Cytologie Analytique, Faculté de Medecine Rockefeller, Université Claude Bernard Lyon I, Lyon, France. [Reis,RM] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.es
dc.contributor.funderCollection of blood samples from Spain, patients from Granada area and DNA extraction was partially supported by grants P08-CVI-4116 from Consejería de Salud de la Junta de Andalucia (Sevilla, Spain) and PI081051 from Fondo de Investigaciones Sanitarias (Madrid, Spain). Collection of blood samples from Polish patients and controls from Lodz area and DNA extraction was supported by a grant from Polish Ministry of Science and Higher Education (No.NN402178334).
dc.date.accessioned2013-11-15T10:24:58Z
dc.date.available2013-11-15T10:24:58Z
dc.date.issued2012-03
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't; Review;es
dc.description.abstractThere is strong evidence suggesting the presence of a genetic component in the aetiology of multiple myeloma (MM). However no genetic risk factors have been unequivocally established so far. To further our understanding of the genetic determinants of MM risk, a promising strategy is to collect a large set of patients in a consortium, as successfully done for other cancers. In this article, we review the main findings in the genetic susceptibility and pharmacogenetics of MM and present the strategy of the IMMEnSE (International Multiple Myeloma rESEarch) consortium in contributing to determine the role of genetic variation in pharmacogenetics and in MM risk.es
dc.description.versionYeses
dc.identifier.citationMartino A, Sainz J, Buda G, Jamroziak K, Reis RM, García-Sanz R, et al. Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review). Int. J. Oncol. 2012; 40(3):625-38es
dc.identifier.doi10.3892/ijo.2011.1284
dc.identifier.essn1791-2423
dc.identifier.issn1019-6439
dc.identifier.pmid22159523
dc.identifier.urihttp://hdl.handle.net/10668/1379
dc.journal.titleInternational journal of oncology
dc.language.isoen
dc.publisherSpandidos Publicationses
dc.relation.publisherversionhttp://www.spandidos-publications.com/ijo/40/3/625es
dc.rights.accessRightsopen access
dc.subjectIMMEnSE consortium,es
dc.subjectMultiple myelomaes
dc.subjectSNPses
dc.subjectGenetic susceptibilityes
dc.subjectHharmacogeneticses
dc.subjectHumanoses
dc.subjectVariación Genéticaes
dc.subjectFarmacogenéticaes
dc.subjectFactores de Riesg0es
dc.subjectMieloma Múltiplees
dc.subjectEpidemiología Moleculares
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variationes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Molecular Epidemiologyes
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple Myelomaes
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Pharmacogeneticses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factorses
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Diseasees
dc.titleGenetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review).es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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