Publication: Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: possible implication in Parkinson's disease incidence.
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Identifiers
Date
2011-02-21
Authors
Machado, A.
Herrera, A.J.
Venero, J.L.
Santiago, M.
De Pablos, R.M.
Villarán, R.F.
Espinosa-Oliva, A.M.
Argüelles, S.
Sarmiento, M.
Delgado-Cortés, M.J.
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi Publishing Corporation
Abstract
Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation enhances the degeneration of the nigrostriatal dopaminergic system induced by different insults; different peripheral inflammations have been used, such as IL-1β and the ulcerative colitis model, as well as insults to the dopaminergic system such as 6-hydroxydopamine or lipopolysaccharide. In all cases, an increased loss of dopaminergic neurons was described; inflammation in the substantia nigra increased, displaying a great activation of microglia along with an increase in the production of cytokines such as IL-1β and TNF-α. Increased permeability or disruption of the BBB, with overexpression of the ICAM-1 adhesion molecule and infiltration of circulating monocytes into the substantia nigra, is also involved, since the depletion of circulating monocytes prevents the effects of peripheral inflammation. Data are reviewed in relation to epidemiological studies of PD.
Description
Review Article
MeSH Terms
Medical Subject Headings::Anatomy::Nervous System::Peripheral Nervous System
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Catecholamines::Dopamine
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Brain Stem::Mesencephalon::Tegmentum Mesencephali::Substantia Nigra
Medical Subject Headings::Publication Characteristics::Publication Formats::Journal Article::Review
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Catecholamines::Dopamine
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Brain Stem::Mesencephalon::Tegmentum Mesencephali::Substantia Nigra
Medical Subject Headings::Publication Characteristics::Publication Formats::Journal Article::Review
DeCS Terms
CIE Terms
Keywords
Enfermedad de Parkinson, Sustancia negra
Citation
Machado A, Herrera AJ, Venero JL, Santiago M, De Pablos RM, Villarán RF. Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence.Parkinsons Dis.2011;(2011): Article ID393769