Publication: Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572
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Date
2021-05-29
Authors
Diez-Echave, Patricia
Martín-Cabrejas, Izaskun
Garrido-Mesa, José
Langa, Susana
Vezza, Teresa
Landete, José M.
Hidalgo-García, Laura
Algieri, Francesca
Mayer, Melinda J.
Narbad, Arjan
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Abstract
Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.
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MeSH Terms
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Aldehydes::Glyceraldehyde
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Lactobacillaceae::Lactobacillus::Lactobacillus reuteri
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL
Medical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements::Probiotics
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Acyclic::Alkanes::Propane
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Glucans::Dextrans::Dextran Sulfate
Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
Medical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dairy Products
Medical Subject Headings::Anatomy::Cells::Myeloid Cells::Macrophages
Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Aldehydes::Glyceraldehyde
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Lactobacillaceae::Lactobacillus::Lactobacillus reuteri
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL
Medical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements::Probiotics
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Acyclic::Alkanes::Propane
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Glucans::Dextrans::Dextran Sulfate
Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
Medical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dairy Products
Medical Subject Headings::Anatomy::Cells::Myeloid Cells::Macrophages
DeCS Terms
CIE Terms
Keywords
Limosilactobacillus reuteri, Probiotic, Colonic model, DSS-induced colitic model, Immunomodulation, Reuterin, Protective effect, Dextran sulphate sodium, Cell line, Macrophages, Lactobacillus reuteri, Probióticos, Inmunomodulación, Protectores contra radiación, Sulfato de Dextran, Línea Celular, Macrófagos
Citation
Diez-Echave P, Martín-Cabrejas I, Garrido-Mesa J, Langa S, Vezza T, Landete JM, Hidalgo-García L, et al. Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572. Nutrients. 2021 May 29;13(6):1860