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Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity

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dc.contributor.authorCárdenas, Casimiro
dc.contributor.authorTorres-Vargas, José Antonio
dc.contributor.authorCárdenas-Valdivia, Abel
dc.contributor.authorJurado, Nuria
dc.contributor.authorQuesada, Ana R.
dc.contributor.authorGarcía-Caballero, Melissa
dc.contributor.authorMartínez-Poveda, Beatriz
dc.contributor.authorMedina, Miguel Ángel
dc.contributor.authoraffiliation[Cárdenas,C; Torres-Vargas,JA; Jurado,N; Quesada,AR; García-Caballero,M; Martínez-Poveda,B; Medina,MÁ] Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Málaga, Spain. [Cárdenas,C] Research Support Central Services (SCAI) of the University of Málaga, Spain. [Torres-Vargas,JA; Quesada,AR; García-Caballero,M; Martínez-Poveda,B; Medina,MÁ] IBIMA (Biomedical Research Institute of Málaga), Málaga, Spain. [Cárdenas-Valdivia,A] Department of Physical Chemistry, Faculty of Sciences, University of Malaga, Malaga, Spain. [Quesada,AR; Medina,MÁ] CIBER de Enfermedades Raras (CIBERER), Málaga, Spain. [Martínez-Poveda,B] CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
dc.contributor.funderThis work was supported by grants PID2019-105010RB-I00 (Spanish Ministry of Science, Innovation and Universities), UMA18-FEDERJA 220, UMA18-FEDERJA-267 and PY20_00257 (Andalusian Government and FEDER) and funds from group BIO 267 (Andalusian Government). The “CIBER de Enfermedades Raras” and “CIBER de Enfermedades Vasculares” are initiatives from the ISCIII (Spain).
dc.date.accessioned2023-01-18T13:03:11Z
dc.date.available2023-01-18T13:03:11Z
dc.date.issued2021-10-06
dc.description.abstractThe tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.es_ES
dc.description.versionYeses_ES
dc.identifier.citationCárdenas C, Torres-Vargas JA, Cárdenas-Valdivia A, Jurado N, Quesada AR, García-Caballero M, et al. Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity. Biomed Pharmacother. 2021 Dec;144:112263es_ES
dc.identifier.doi10.1016/j.biopha.2021.112263es_ES
dc.identifier.essn1950-6007
dc.identifier.issn0753-3322
dc.identifier.pmid34626933es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4594
dc.journal.titleBiomedicine & Pharmacotherapy
dc.language.isoen
dc.page.number10 p.
dc.publisherElsevier Masson SASes_ES
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0753332221010477?via%3Dihubes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectUltra-high-performance liquides_ES
dc.subjectChromatography-high-resolution mass spectrometry (UHPLC–HRMS)es_ES
dc.subjectAnnona muricataes_ES
dc.subjectGraviolaes_ES
dc.subjectSoursopes_ES
dc.subjectAngiogenesises_ES
dc.subjectCromatografía líquida de alta presiónes_ES
dc.subjectEspectrometría de masases_ES
dc.subjectAnnonaceaees_ES
dc.subjectAnnonaes_ES
dc.subjectNeovascularización fisiológicaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Angiogenesis Modulating Agents::Angiogenesis Inhibitorses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Ruminants::Cattlees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiationes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movementes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Chromatography::Chromatography, Liquid::Chromatography, High Pressure Liquides_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Epithelial Cells::Endothelial Cellses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolomees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Cardiovascular Physiological Processes::Neovascularization, Physiologices_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Phytochemicalses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Plant Preparations::Plant Extractses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry::Spectrometry, Mass, Electrospray Ionizationes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Annonaceae::Annonaes_ES
dc.titleNon-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activityes_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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