Publication: Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients.
dc.contributor.author | Araos, Pedro | |
dc.contributor.author | Vidal, Rebeca | |
dc.contributor.author | O'Shea, Esther | |
dc.contributor.author | Pedraz, Maria | |
dc.contributor.author | Garcia-Marchena, Nuria | |
dc.contributor.author | Serrano, Antonia | |
dc.contributor.author | Suarez, Juan | |
dc.contributor.author | Castilla-Ortega, Estela | |
dc.contributor.author | Ruiz, Juan Jesus | |
dc.contributor.author | Campos-Cloute, Rafael | |
dc.contributor.author | Santin, Luis J | |
dc.contributor.author | Rodriguez-de-Fonseca, Fernando | |
dc.contributor.author | Pavon, Francisco Javier | |
dc.contributor.author | Colado, Maria Isabel | |
dc.contributor.funder | RETICS Red de Trastornos Adictivos | |
dc.contributor.funder | Instituto de Salud Carlos III (ISC-III) | |
dc.contributor.funder | European Regional Development Funds European Union (ERDF-EU) | |
dc.contributor.funder | Ministerio de Economía y Competitividad | |
dc.contributor.funder | Ministerio de Sanidad, Servicios Sociales e Igualdad and Plan Nacional sobre Drogas | |
dc.contributor.funder | Consejería de Economía, Innovación y Ciencia, Junta de Andalucía | |
dc.date.accessioned | 2023-02-08T14:37:31Z | |
dc.date.available | 2023-02-08T14:37:31Z | |
dc.date.issued | 2019-11-14 | |
dc.description.abstract | The lack of effective treatments and a high rate of relapse in cocaine addiction constitute a major health problem. The present study was conducted to examine the expression of tryptophan-derived metabolites in the context of cocaine addiction and psychiatric comorbidity, which is common in addicted subjects. Abstinent patients with cocaine use disorder (CUD) and control subjects were recruited for a cross-sectional study. Participants were assessed with a semi-structured diagnostic interview (PRISM) based on DSM-IV-TR for substance and mental disorders. Plasma concentrations of tryptophan metabolites and their association with relevant CUD-related variables and psychiatric comorbidity were explored. We observed decreased plasma kynurenic acid concentrations in the cocaine group, however no associations between CUD-related variables and tryptophan-derived metabolites were found. In contrast, 5-HT concentrations were increased in CUD-patients and the diagnosis of different psychiatric disorders in the cocaine group was related to higher plasma 5-HT concentrations compared with non-comorbid patients. Therefore, while changes in plasma kynurenic acid concentrations appear to be directly associated with lifetime CUD, changes in 5-HT concentrations are associated with psychiatric comorbidity. These results emphasize the need to find potential biomarkers for a better stratification of cocaine-addicted patients in order to develop therapeutic approaches to prevent cocaine relapse. | |
dc.description.sponsorship | The present study was supported by RETICS Red de Trastornos Adictivos (RD16/0017/0001 and RD16/0017/0021) funded by Instituto de Salud Carlos III (ISC-III) and European Regional Development FundsEuropean Union (ERDF-EU); Research projects funded by Ministerio de Economía y Competitividad and ISC-III (PI16/01698 and PI16/01953); Research project funded by Ministerio de Economía y Competitividad (PSI2013-44901-P to LJS); Research project funded by Ministerio de Sanidad, Servicios Sociales e Igualdad and Plan Nacional sobre Drogas (PNSD 049/2013 and PNSD 2017I017); Research project funded by Consejería de Economía, Innovación y Ciencia, Junta de Andalucía and ERDF-EU (CTS-433). JS, AS and FJP hold Miguel Servet research contracts funded by ISC-III and ERDF-EU (CP12/03109, CP14/00173 and CP14/00212, respectively). EC-O holds a Young Research grant funded by Ministerio de Economía y Competitividad (Agencia Estatal de Investigación) and ERDF-EU (PSI2015-73156-JIN). PA received a Plan Propio grant from Universidad de Málaga (Incorporación Doctores CI-17-415). | |
dc.description.version | Si | |
dc.identifier.citation | Araos P, Vidal R, O'Shea E, Pedraz M, García-Marchena N, Serrano A, et al. Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients. Sci Rep. 2019 Nov 14;9(1):16842 | |
dc.identifier.doi | 10.1038/s41598-019-53312-0 | |
dc.identifier.essn | 2045-2322 | |
dc.identifier.pmc | PMC6856167 | |
dc.identifier.pmid | 31727978 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856167/pdf | |
dc.identifier.unpaywallURL | https://www.nature.com/articles/s41598-019-53312-0.pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/14691 | |
dc.issue.number | 1 | |
dc.journal.title | Scientific reports | |
dc.journal.titleabbreviation | Sci Rep | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Regional de Málaga | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.page.number | 11 | |
dc.provenance | Realizada la curación de contenido 12/05/2025 | |
dc.publisher | Nature Publishing Group | |
dc.pubmedtype | Journal Article | |
dc.pubmedtype | Research Support, Non-U.S. Gov't | |
dc.relation.projectID | RD16/0017/0001 | |
dc.relation.projectID | PI16/01698 | |
dc.relation.projectID | PSI2013-44901-P | |
dc.relation.projectID | PNSD049/2013 | |
dc.relation.projectID | CTS-433 | |
dc.relation.projectID | CP12/03109 | |
dc.relation.projectID | PSI2015-73156-JIN | |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-019-53312-0 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Kynurenic Acid | |
dc.subject | Mental Disorders | |
dc.subject | Serotonin | |
dc.subject | Tryptophan | |
dc.subject.decs | Cocaína | |
dc.subject.decs | Serotonina | |
dc.subject.decs | Triptófano | |
dc.subject.decs | Trastornos mentales | |
dc.subject.decs | Trastornos relacionados con cocaína | |
dc.subject.decs | Ácido Quinurénico | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Cocaine-Related Disorders | |
dc.subject.mesh | Comorbidity | |
dc.subject.mesh | Cross-Sectional Studies | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.title | Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 9 | |
dspace.entity.type | Publication |