Publication:
Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients.

dc.contributor.authorAraos, Pedro
dc.contributor.authorVidal, Rebeca
dc.contributor.authorO'Shea, Esther
dc.contributor.authorPedraz, Maria
dc.contributor.authorGarcia-Marchena, Nuria
dc.contributor.authorSerrano, Antonia
dc.contributor.authorSuarez, Juan
dc.contributor.authorCastilla-Ortega, Estela
dc.contributor.authorRuiz, Juan Jesus
dc.contributor.authorCampos-Cloute, Rafael
dc.contributor.authorSantin, Luis J
dc.contributor.authorRodriguez-de-Fonseca, Fernando
dc.contributor.authorPavon, Francisco Javier
dc.contributor.authorColado, Maria Isabel
dc.contributor.funderRETICS Red de Trastornos Adictivos
dc.contributor.funderInstituto de Salud Carlos III (ISC-III)
dc.contributor.funderEuropean Regional Development Funds European Union (ERDF-EU)
dc.contributor.funderMinisterio de Economía y Competitividad
dc.contributor.funderMinisterio de Sanidad, Servicios Sociales e Igualdad and Plan Nacional sobre Drogas
dc.contributor.funderConsejería de Economía, Innovación y Ciencia, Junta de Andalucía
dc.date.accessioned2023-02-08T14:37:31Z
dc.date.available2023-02-08T14:37:31Z
dc.date.issued2019-11-14
dc.description.abstractThe lack of effective treatments and a high rate of relapse in cocaine addiction constitute a major health problem. The present study was conducted to examine the expression of tryptophan-derived metabolites in the context of cocaine addiction and psychiatric comorbidity, which is common in addicted subjects. Abstinent patients with cocaine use disorder (CUD) and control subjects were recruited for a cross-sectional study. Participants were assessed with a semi-structured diagnostic interview (PRISM) based on DSM-IV-TR for substance and mental disorders. Plasma concentrations of tryptophan metabolites and their association with relevant CUD-related variables and psychiatric comorbidity were explored. We observed decreased plasma kynurenic acid concentrations in the cocaine group, however no associations between CUD-related variables and tryptophan-derived metabolites were found. In contrast, 5-HT concentrations were increased in CUD-patients and the diagnosis of different psychiatric disorders in the cocaine group was related to higher plasma 5-HT concentrations compared with non-comorbid patients. Therefore, while changes in plasma kynurenic acid concentrations appear to be directly associated with lifetime CUD, changes in 5-HT concentrations are associated with psychiatric comorbidity. These results emphasize the need to find potential biomarkers for a better stratification of cocaine-addicted patients in order to develop therapeutic approaches to prevent cocaine relapse.
dc.description.sponsorshipThe present study was supported by RETICS Red de Trastornos Adictivos (RD16/0017/0001 and RD16/0017/0021) funded by Instituto de Salud Carlos III (ISC-III) and European Regional Development FundsEuropean Union (ERDF-EU); Research projects funded by Ministerio de Economía y Competitividad and ISC-III (PI16/01698 and PI16/01953); Research project funded by Ministerio de Economía y Competitividad (PSI2013-44901-P to LJS); Research project funded by Ministerio de Sanidad, Servicios Sociales e Igualdad and Plan Nacional sobre Drogas (PNSD 049/2013 and PNSD 2017I017); Research project funded by Consejería de Economía, Innovación y Ciencia, Junta de Andalucía and ERDF-EU (CTS-433). JS, AS and FJP hold Miguel Servet research contracts funded by ISC-III and ERDF-EU (CP12/03109, CP14/00173 and CP14/00212, respectively). EC-O holds a Young Research grant funded by Ministerio de Economía y Competitividad (Agencia Estatal de Investigación) and ERDF-EU (PSI2015-73156-JIN). PA received a Plan Propio grant from Universidad de Málaga (Incorporación Doctores CI-17-415).
dc.description.versionSi
dc.identifier.citationAraos P, Vidal R, O'Shea E, Pedraz M, García-Marchena N, Serrano A, et al. Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients. Sci Rep. 2019 Nov 14;9(1):16842
dc.identifier.doi10.1038/s41598-019-53312-0
dc.identifier.essn2045-2322
dc.identifier.pmcPMC6856167
dc.identifier.pmid31727978
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856167/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41598-019-53312-0.pdf
dc.identifier.urihttp://hdl.handle.net/10668/14691
dc.issue.number1
dc.journal.titleScientific reports
dc.journal.titleabbreviationSci Rep
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number11
dc.provenanceRealizada la curación de contenido 12/05/2025
dc.publisherNature Publishing Group
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDRD16/0017/0001
dc.relation.projectIDPI16/01698
dc.relation.projectIDPSI2013-44901-P
dc.relation.projectIDPNSD049/2013
dc.relation.projectIDCTS-433
dc.relation.projectIDCP12/03109
dc.relation.projectIDPSI2015-73156-JIN
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-53312-0
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectKynurenic Acid
dc.subjectMental Disorders
dc.subjectSerotonin
dc.subjectTryptophan
dc.subject.decsCocaína
dc.subject.decsSerotonina
dc.subject.decsTriptófano
dc.subject.decsTrastornos mentales
dc.subject.decsTrastornos relacionados con cocaína
dc.subject.decsÁcido Quinurénico
dc.subject.meshAdult
dc.subject.meshCase-Control Studies
dc.subject.meshCocaine-Related Disorders
dc.subject.meshComorbidity
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.titleSerotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
PMC6856167.pdf
Size:
1.29 MB
Format:
Adobe Portable Document Format
No Thumbnail Available
Name:
Araos_SerotoninIsThe_MaterialSuplementario.pdf
Size:
154.38 KB
Format:
Adobe Portable Document Format