Clinical Performance of Commercial ISAC 112 Allergen Microarray Versus Noncommercial RIRAAF Platform for the Diagnosis of Plant Food and Olive Pollen Allergies.

Abstract

The combination of molecular biology and technological advances in recent years has enabled the development of new methods for determining serum specific IgE (sIgE) [1] to different allergens using a single determination method with minimal quantities of allergen and serum [2]. However, to achieve an accurate diagnostic assessment, it is still important to apply an adequate panel of allergens [3]. The ImmunoCAP ISAC 112 microarray (Thermo Fisher Scientific) is the only commercially available allergenic protein microarray, but its current panel of allergens does not seem to have the best accuracy when diagnosing food or pollen allergies in certain regions [3]. Indeed, some authors have even suggested including other allergens [3,4]. As part of the Spanish National Research Network of adverse reactions to allergens and drugs (RIRAAF), our team recently developed a new allergenic protein microarray model.