Publication:
18FDG PET/CT & arterial inflammation: predicting cardiovascular events in lung cancer.

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2019

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Villena García, A C
Cardo, A Gutierrez
Hidalgo, C M
Palomo, L
Lillo, E
Espíldora, J
Trigo, J Manuel
Chaparro, M Á Sánchez
Valdivielso, P

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18F-FDG PET/CT predicts cardiovascular disease. To analyze the predictive value of cardiovascular events from inflammation and arterial calcification in patients who underwent an 18F-FDG PET/CT for lung cancer. A retrospective study of 274 patients with primary lung neoplasia. We determined: (i) TBR (target-to-background ratio), and (ii) the calcium score, at eight common arterial segments. We took as arteriosclerosis, a TBR ≥1.6 and ≥15 Calcium Score sum. We registered cardiovascular risk factors, comorbidities, histology, stage, treatment, status at the last clinical review, cause of death and cardiovascular event during the follow-up. The territory presenting the greatest uptake of 18F-FDG, was the thoracic aorta with an average of 1.77 (± 0.27 TBR) in the aortic arch, while the greatest degree of calcification was obtained in the abdominal aorta (52% with a Calcium Score ≥ 3). 24% of the patients presented a sum Calcium Score ≥15, and 17% a TBR ≥1.6. Patients with high TBR, (17%), had not a higher frequency of cardiovascular comorbidities beforehand, nor did they in the follow-up. However, those with a sum Calcium Score ≥15 (24%), were older, had more cardiovascular risk factors and ischemic events during follow-up. The calcium score, but not the TBR, predicted the emergence of a cardiovascular event (HR 4.9 IC95% 2.1-9.1, P In our cohort, a high Calcium Score was an independent predictor for developing cardiovascular events.

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Aged
Aorta, Abdominal
Aorta, Thoracic
Arteritis
Atherosclerosis
Calcinosis
Cardiovascular Diseases
Female
Fluorodeoxyglucose F18
Humans
Lung Neoplasms
Male
Middle Aged
Positron Emission Tomography Computed Tomography
Proportional Hazards Models
Retrospective Studies
Risk Factors

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