Publication:
Systolic blood pressure and mortality in acute symptomatic pulmonary embolism.

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Date

2019-11-14

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Quezada, Andrés
Jiménez, David
Bikdeli, Behnood
Moores, Lisa
Porres-Aguilar, Mateo
Aramberri, Mario
Lima, Jorge
Ballaz, Aitor
Yusen, Roger D
Monreal, Manuel

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Abstract

The optimal cutoff for systolic blood pressure (SBP) level to define high-risk pulmonary embolism (PE) remains to be defined. To evaluate the relationship between SBP levels on admission and mortality in patients with acute symptomatic PE, the current study included 39,257 consecutive patients with acute symptomatic PE from the RIETE registry between 2001 and 2018. Primary outcomes included all-cause and PE-specific 30-day mortality. Secondary outcomes included major bleeding and recurrent venous thromboembolism (VTE). There was a linear inverse relationship between admission SBP and 30-day all-cause and PE-related mortality that persisted after multivariable adjustment. Patients in the lower SBP strata had higher rates of all-cause death (reference: SBP 110-129 mmHg) (adjusted odds ratio [OR] 2.9; 95% confidence interval [CI], 2.0-4.2 for SBP 190 mmHg). Consistent findings were also observed for 30-day PE-related death. In patients with acute symptomatic PE, a low SBP portends an increased risk of all-cause and PE-related mortality. The highest mortality was observed in patients with SBP

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MeSH Terms

Acute Disease
Aged
Aged, 80 and over
Blood Pressure
Canada
Cause of Death
Female
Humans
Male
Prospective Studies
Pulmonary Embolism
Registries
Spain
Survival Rate
Systole
United States

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Keywords

Mortality, Pulmonary embolism, Systolic blood pressure

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