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Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients.

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dc.contributor.authorMacauda, Angelica
dc.contributor.authorPiredda, Chiara
dc.contributor.authorClay-Gilmour, Alyssa I
dc.contributor.authorSainz, Juan
dc.contributor.authorBuda, Gabriele
dc.contributor.authorMarkiewicz, Miroslaw
dc.contributor.authorBarington, Torben
dc.contributor.authorZiv, Elad
dc.contributor.authorHildebrandt, Michelle A T
dc.contributor.authorBelachew, Alem A
dc.contributor.authorVarkonyi, Judit
dc.contributor.authorPrejzner, Witold
dc.contributor.authorDruzd-Sitek, Agnieszka
dc.contributor.authorSpinelli, John
dc.contributor.authorAndersen, Niels Frost
dc.contributor.authorHofmann, Jonathan N
dc.contributor.authorDudziński, Marek
dc.contributor.authorMartinez-Lopez, Joaquin
dc.contributor.authorIskierka-Jazdzewska, Elzbieta
dc.contributor.authorMilne, Roger L
dc.contributor.authorMazur, Grzegorz
dc.contributor.authorGiles, Graham G
dc.contributor.authorEbbesen, Lene Hyldahl
dc.contributor.authorRymko, Marcin
dc.contributor.authorJamroziak, Krzysztof
dc.contributor.authorSubocz, Edyta
dc.contributor.authorReis, Rui Manuel
dc.contributor.authorGarcia-Sanz, Ramon
dc.contributor.authorSuska, Anna
dc.contributor.authorHaastrup, Eva Kannik
dc.contributor.authorZawirska, Daria
dc.contributor.authorGrzasko, Norbert
dc.contributor.authorVangsted, Annette Juul
dc.contributor.authorDumontet, Charles
dc.contributor.authorKruszewski, Marcin
dc.contributor.authorDutka, Magdalena
dc.contributor.authorCamp, Nicola J
dc.contributor.authorWaller, Rosalie G
dc.contributor.authorTomczak, Waldemar
dc.contributor.authorPelosini, Matteo
dc.contributor.authorRaźny, Małgorzata
dc.contributor.authorMarques, Herlander
dc.contributor.authorAbildgaard, Niels
dc.contributor.authorWątek, Marzena
dc.contributor.authorJurczyszyn, Artur
dc.contributor.authorBrown, Elizabeth E
dc.contributor.authorBerndt, Sonja
dc.contributor.authorButrym, Aleksandra
dc.contributor.authorVachon, Celine M
dc.contributor.authorNorman, Aaron D
dc.contributor.authorSlager, Susan L
dc.contributor.authorGemignani, Federica
dc.contributor.authorCanzian, Federico
dc.contributor.authorCampa, Daniele
dc.date.accessioned2023-02-09T10:45:06Z
dc.date.available2023-02-09T10:45:06Z
dc.date.issued2021-03-30
dc.description.abstractGene expression profiling can be used for predicting survival in multiple myeloma (MM) and identifying patients who will benefit from particular types of therapy. Some germline single nucleotide polymorphisms (SNPs) act as expression quantitative trait loci (eQTLs) showing strong associations with gene expression levels. We performed an association study to test whether eQTLs of genes reported to be associated with prognosis of MM patients are directly associated with measures of adverse outcome. Using the genotype-tissue expression portal, we identified a total of 16 candidate genes with at least one eQTL SNP associated with their expression with P 
dc.identifier.doi10.1002/ijc.33547
dc.identifier.essn1097-0215
dc.identifier.pmcPMC8770990
dc.identifier.pmid33675538
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770990/pdf
dc.identifier.unpaywallURLhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.33547
dc.identifier.urihttp://hdl.handle.net/10668/17318
dc.issue.number2
dc.journal.titleInternational journal of cancer
dc.journal.titleabbreviationInt J Cancer
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.page.number327-336
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjecteQTL
dc.subjectgenetic polymorphisms
dc.subjectmultiple myeloma
dc.subjectoverall survival
dc.subjectprogression-free survival
dc.subject.meshAged
dc.subject.meshApyrase
dc.subject.meshFemale
dc.subject.meshGene Expression Profiling
dc.subject.meshGenetic Association Studies
dc.subject.meshGerm-Line Mutation
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMitochondrial Proteins
dc.subject.meshMultiple Myeloma
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshQuantitative Trait Loci
dc.subject.meshRNA-Binding Proteins
dc.subject.meshSurvival Analysis
dc.titleExpression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number149
dspace.entity.typePublication

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