Publication: Erythema Nodosum as Azathioprine Hypersensitivity Reaction in a Patient with Bullous Pemphigoid.
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Date
2013-08-30
Authors
Vargas-Hitos, Jose Antonio
Sabio, Jose Mario
Tercedor, Jesús
Navarrete-Navarrete, Nuria
Jiménez-Alonso, Juan
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Publisher
Medknow Publications
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Abstract
A 65-year-old woman with bullous pemphigoid presented with fever and several red-purple nodular subcutaneous lesions on both lower legs 1 week after starting treatment with azathioprine (AZA). Biopsy of a skin nodule was compatible with erythema nodosum (EN) and hypersensitivity reaction to AZA was suspected. AZA was subsequently discontinued, observing complete remission of fever and EN within 2 weeks. This case highlights the importance of recognizing EN as a possible manifestation of hypersensitivity reaction to AZA.
Description
JOURNAL ARTICLE;
MeSH Terms
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thionucleosides::Azathioprine
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Erythema::Erythema Nodosum
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Vesiculobullous::Pemphigoid, Bullous
Medical Subject Headings::Diseases::Immune System Diseases::Hypersensitivity::Drug Hypersensitivity
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Erythema::Erythema Nodosum
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Vesiculobullous::Pemphigoid, Bullous
Medical Subject Headings::Diseases::Immune System Diseases::Hypersensitivity::Drug Hypersensitivity
Medical Subject Headings::Check Tags::Female
DeCS Terms
CIE Terms
Keywords
Azathioprine, bullous pemphigoid, erythema nodosum, hypersensitivity syndrome, Azatioprina, Eritema Nudoso, Penfigoide Ampolloso, Hipersensibilidad a las Drogas, Femenino
Citation
Vargas-Hitos JA, Sabio JM, Tercedor J, Navarrete-Navarrete N, Jiménez-Alonso J. Erythema Nodosum as Azathioprine Hypersensitivity Reaction in a Patient with Bullous Pemphigoid. Indian J Dermatol. 2013 ; 58(5):406