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Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions

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dc.contributor.authorMartin-Gutierrez, Guillermo
dc.contributor.author Rodriguez-Martinez, Jose Manuel
dc.contributor.authorPascual, Alvaro
dc.contributor.authorRodriguez-Beltran, Jeronimo
dc.contributor.authorBlazquez, Jesus
dc.contributor.authoraffiliation[Martin-Gutierrez, Guillermo] Univ Seville, Univ Hosp Virgen Roc, CSIC, IBIS, Seville, Spain
dc.contributor.authoraffiliation[Manuel Rodriguez-Martinez, Jose] Univ Seville, Univ Hosp Virgen Roc, CSIC, IBIS, Seville, Spain
dc.contributor.authoraffiliation[Pascual, Alvaro] Univ Seville, Univ Hosp Virgen Roc, CSIC, IBIS, Seville, Spain
dc.contributor.authoraffiliation[Rodriguez-Beltran, Jeronimo] Univ Seville, Univ Hosp Virgen Roc, CSIC, IBIS, Seville, Spain
dc.contributor.authoraffiliation[Blazquez, Jesus] Univ Seville, Univ Hosp Virgen Roc, CSIC, IBIS, Seville, Spain
dc.contributor.authoraffiliation[Manuel Rodriguez-Martinez, Jose] Univ Seville, Dept Microbiol, Seville, Spain
dc.contributor.authoraffiliation[Pascual, Alvaro] Univ Seville, Dept Microbiol, Seville, Spain
dc.contributor.authoraffiliation[Pascual, Alvaro] Hosp Univ Virgen Macarena & Virgen Rocio, Unidad Intercentros Enfermedades Infecciosas Micr, Seville, Spain
dc.contributor.authoraffiliation[Blazquez, Jesus] Hosp Univ Virgen Macarena & Virgen Rocio, Unidad Intercentros Enfermedades Infecciosas Micr, Seville, Spain
dc.contributor.authoraffiliation[Blazquez, Jesus] CSIC, CNB, Madrid, Spain
dc.date.accessioned2023-02-12T02:21:40Z
dc.date.available2023-02-12T02:21:40Z
dc.date.issued2017-04
dc.description.abstractEscherichia coli variants expressing plasmid- mediated qnr genes are usually susceptible to fluoroquinolones by standard susceptibility testing. Here we show that, under specific urinary tract physiological conditions, susceptible laboratory and clinical strains harboring qnr determinants become fully resistant to ciprofloxacin (CIP). Therefore, physiological conditions, mainly urine pH values, should be considered when performing susceptibility testing of CIP activity against E. coli in treating urinary tract infection (UTI) and for selecting appropriate antibiotics for UTI treatment.
dc.description.versionSi
dc.identifier.citationMartín-Gutiérrez G, Rodríguez-Martínez JM, Pascual Á, Rodríguez-Beltrán J, Blázquez J. Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02615-16
dc.identifier.doi10.1128/AAC.02615-16
dc.identifier.essn1098-6596
dc.identifier.issn0066-4804
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc5365700?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/19015
dc.identifier.wosID397598800079
dc.issue.number4
dc.journal.titleAntimicrobial agents and chemotherapy
dc.journal.titleabbreviationAntimicrob. agents chemother.
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationHospital Universitario Virgen Macarena
dc.page.number4
dc.provenanceRealizada la curación de contenido 27/06/2025.
dc.publisherAmer soc microbiology
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/AAC.02615-16?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.rights.accessRightsRestricted Access
dc.subjectciprofloxacin
dc.subjectEscherichia coli
dc.subjectMIC
dc.subjectpH
dc.subjectqnr
dc.subjecturinary tract infection
dc.subjectMediated quinolone resistance
dc.subjectFluoroquinolone resistance
dc.subjectEscherichia-coli
dc.subjectKlebsiella-pneumoniae
dc.subjectAac(6')-ib-cr
dc.subjectEpidemiology
dc.subjectInfections
dc.subjectMutations
dc.subject.decsInfecciones urinarias
dc.subject.decsCiprofloxacina
dc.subject.decsFluoroquinolonas
dc.subject.decsAntibacterianos
dc.subject.decsPlásmidos
dc.subject.decsLaboratorios
dc.subject.mesh Ciprofloxacin
dc.subject.mesh Anti-Bacterial Agents
dc.subject.mesh Fluoroquinolones
dc.subject.mesh Escherichia coli
dc.subject.mesh Urinary Tract Infections
dc.subject.meshPlasmids
dc.subject.mesh Hydrogen-Ion Concentration
dc.titlePlasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number61
dc.wostypeArticle
dspace.entity.typePublication

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