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Imaging biomarkers for steatohepatitis and fibrosis detection in non-alcoholic fatty liver disease.

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dc.contributor.authorGallego-Durán, Rocío
dc.contributor.authorCerro-Salido, Pablo
dc.contributor.authorGomez-Gonzalez, Emilio
dc.contributor.authorPareja, María Jesús
dc.contributor.authorAmpuero, Javier
dc.contributor.authorRico, María Carmen
dc.contributor.authorAznar, Rafael
dc.contributor.authorVilar-Gomez, Eduardo
dc.contributor.authorBugianesi, Elisabetta
dc.contributor.authorCrespo, Javier
dc.contributor.authorGonzález-Sánchez, Francisco José
dc.contributor.authorAparcero, Reyes
dc.contributor.authorMoreno, Inmaculada
dc.contributor.authorSoto, Susana
dc.contributor.authorArias-Loste, María Teresa
dc.contributor.authorAbad, Javier
dc.contributor.authorRanchal, Isidora
dc.contributor.authorAndrade, Raúl Jesús
dc.contributor.authorCalleja, Jose Luis
dc.contributor.authorPastrana, Miguel
dc.contributor.authorLo Iacono, Oreste
dc.contributor.authorRomero-Gómez, Manuel
dc.contributor.authoraffiliation[Gallego-Durán,R; Ampuero,J; Rico,MC; Vilar-Gomez,E; Ranchal,I; Romero-Gómez,M] UCM Digestive Diseases and CIBEREHD, Virgen Macarena-Virgen del Rocío University Hospitals, University of Sevilla. Instituto de Biomedicina de Sevilla (IBiS), University of Sevilla, Sevilla, Spain. [Cerro-Salido,P; Gomez-Gonzalez,E] Group of Interdisciplinary Physics, Engineering School, University of Sevilla, Sevilla, Spain. [Pareja,MJ] Pathology Unit, Valme University Hospital, University of Sevilla, Sevilla, Spain. [Aznar,R] Radiology Unit, Valme University Hospital, University of Sevilla, Sevilla, Spain. [Bugianesi,E] Medical Sciences, University of Torino, Torino, Italy. [Crespo,J; Arias-Loste,MT] IDIVAL, Marqués de Valdecilla University Hospital, Gastroenterology and Hepatology Service, Santander, Spain. [González-Sánchez,FJ] Radiology Unit, Marqués de Valdecilla University Hospital, Santander, Spain. [Aparcero,R] UCM Digestive Diseases, Valme University Hospital, Sevilla, Spain. [Moreno,I; Andrade,RJ] UCM Digestive Diseases and CIBEREHD, Virgen de la Victoria University Hospital, Málaga, Spain. [Soto,S; Lo Iacono,O] UCM Digestive Diseases, Tajo University Hospital, Madrid, Spain. [Calleja,JL] UCM Digestive Diseases, Puerta de Hierro University Hospital, Madrid, Spain. [Pastrana,M] Radiology Unit, Puerta de Hierro University Hospital, Madrid, Spain.es
dc.contributor.funderThe research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement #HEALTH-F2-2009-241762 for the project Fatty Liver Inhibition of Progression (FLIP) and from Consejería de Salud de la Junta de Andalucía under grant agreement #PI-0488-2012/2012. Imaging biomarkers (NASHMRI and FibroMRI) are protected by a European patent #EP15382118.
dc.date.accessioned2016-09-22T07:44:09Z
dc.date.available2016-09-22T07:44:09Z
dc.date.issued2016-08-12
dc.descriptionJournal Article;es
dc.description.abstractThere is a need, in NAFLD management, to develop non-invasive methods to detect steatohepatitis (NASH) and to predict advanced fibrosis stages. We evaluated a tool based on optical analysis of liver magnetic resonance images (MRI) as biomarkers for NASH and fibrosis detection by investigating patients with biopsy-proven NAFLD who underwent magnetic resonance (MR) protocols using 1.5T General Electric (GE) or Philips devices. Two imaging biomarkers (NASHMRI and FibroMRI) were developed, standardised and validated using area under the receiver operating characteristic curve (AUROC) analysis. The results indicated NASHMRI diagnostic accuracy for steatohepatitis detection was 0.83 (95% CI: 0.73-0.93) and FibroMRI diagnostic accuracy for significant fibrosis determination was 0.85 (95% CI: 0.77-0.94). These findings were independent of the MR system used. We conclude that optical analysis of MRI has high potential to define non-invasive imaging biomarkers for the detection of steatohepatitis (NASHMRI) and the prediction of significant fibrosis (FibroMRI) in NAFLD patients.es
dc.description.versionYeses
dc.identifier.citationGallego-Durán R, Cerro-Salido P, Gomez-Gonzalez E, Pareja MJ, Ampuero J, Rico MC, et al. Imaging biomarkers for steatohepatitis and fibrosis detection in non-alcoholic fatty liver disease. Sci Rep. 2016; 6:31421es
dc.identifier.doi10.1038/srep31421
dc.identifier.essn2045-2322
dc.identifier.pmcPMC4981860
dc.identifier.pmid27514671
dc.identifier.urihttp://hdl.handle.net/10668/2426
dc.journal.titleScientific Reports
dc.language.isoen
dc.publisherNature Publishing Groupes
dc.relation.publisherversionhttp://www.nature.com/articles/srep31421#abstractes
dc.rights.accessRightsopen access
dc.subjectÁrea bajo la curvaes
dc.subjectBiopsiaes
dc.subjectEspectroscopía de resonancia magnéticaes
dc.subjectCurva ROCes
dc.subjectBiomarcadoreses
dc.subjectEsteatosis hepática no alcohólicaes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Area Under Curvees
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsyes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Spectrum Analysis::Magnetic Resonance Spectroscopyes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::ROC Curvees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biomarkerses
dc.subject.meshMedical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Diseasees
dc.titleImaging biomarkers for steatohepatitis and fibrosis detection in non-alcoholic fatty liver disease.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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