Publication:
Establishment of 2 control and 2 hPSC cell lines constitutively expressing the Notch ligand DLL4.

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dc.contributor.authorGonzález-Pozas, Federico
dc.contributor.authorMontes, Rosa
dc.contributor.authorDomingo-Reinés, Joan
dc.contributor.authorAyllón, Verónica
dc.contributor.authorRamos-Mejía, Verónica
dc.date.accessioned2023-01-25T10:02:03Z
dc.date.available2023-01-25T10:02:03Z
dc.date.issued2017-07-10
dc.description.abstractThe Notch ligand DLL4 has key roles during embryonic development of different tissues, but most of the data comes from animal models. Here we describe the generation and characterization of 2 human Pluripotent Stem Cell (hPSC) lines that overexpress DLL4, as well as the two corresponding control hPSC lines. DLL4 expression can be detected at the mRNA and protein level, and does not affect the pluripotency of the cells. These hPSC lines can be used to study the role of DLL4 during human embryonic development.
dc.identifier.doi10.1016/j.scr.2017.07.008
dc.identifier.essn1876-7753
dc.identifier.pmid29246573
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.scr.2017.07.008
dc.identifier.urihttp://hdl.handle.net/10668/11915
dc.journal.titleStem cell research
dc.journal.titleabbreviationStem Cell Res
dc.language.isoen
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.page.number274-277
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.meshAdaptor Proteins, Signal Transducing
dc.subject.meshAdult
dc.subject.meshCalcium-Binding Proteins
dc.subject.meshCell Differentiation
dc.subject.meshCell Line
dc.subject.meshCell Proliferation
dc.subject.meshCells, Cultured
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIntercellular Signaling Peptides and Proteins
dc.subject.meshPluripotent Stem Cells
dc.subject.meshReceptors, Notch
dc.titleEstablishment of 2 control and 2 hPSC cell lines constitutively expressing the Notch ligand DLL4.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number25
dspace.entity.typePublication

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