Publication:
Pharmacological interactions of phosphate binders.

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Date

2018-07-07

Authors

Bover Sanjuan, Jordi
Navarro-Gonzalez, Juan Francisco
Arenas, M Dolores
Torregrosa, Jose-Vicente
Tamargo Menendez, Juan
de Francisco, Angel Luis Martin
Gonzalez-Parra, Emilio
Lloret Cora, M Jesus
Sanchez Alvarez, J Emilio
Martin-Malo, Alejandro

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Elsevier
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Abstract

The use of phosphate binders is one of basic elements in the treatment of CKD-MBD (“Chronic Kidney Disease-Mineral and Bone Disorder”). It has been well known for decades that phosphate reten tion through direct and indirect mechanisms, contributes to the generation and progression of secondary hyperparathy roidism (SHP) and renal osteodystrophy in chronic kidney disease (CKD).1,2 In fact, phosphate retention blocks all DOI of original article: https://doi.org/10.1016/j.nefro.2018.05.003. ∗ Corresponding author. E-mail address: jbover@fundacio-puigvert.es (J. Bover Sanjuán). hormonal counter-regulatory mechanisms, increases skeletal resistance to PTH and is considered a central factor in the and systemic alterations such as the decrease in calcitriol, increase in fibroblast growth factor-23 (FGF-23), cardiovascular calcifications, premature aging and the high morbi-mortality of these patients.2,3 For all this, phosphate has been considered as “the silent killer” of patients with CKD

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MeSH Terms

Chelating agents
Drug interactions
Humans
Phosphates
Renal insufficiency, chronic
Chronic kidney disease-mineral and bone disorder

DeCS Terms

Fosfatos
Insuficiencia renal crónica
Interacciones farmacológicas
Quelantes
Trastorno mineral y óseo asociado a la enfermedad renal crónica

CIE Terms

Keywords

Phosphates, Fibroblast growth factor-23, Aging, premature, Electronic mail, Renal insufficiency, chronic

Citation

Bover Sanjuán J, Navarro-González JF, Arenas MD, Torregrosa JV, Tamargo Menéndez J, de Francisco ALM, et al. Pharmacological interactions of phosphate binders. Nefrologia (Engl Ed). 2018 Nov-Dec;38(6):573-578. English, Spanish