Publication:
Antioxidants for the Treatment of Breast Cancer: Are We There Yet?

Loading...
Thumbnail Image

Date

2021-01-31

Authors

Griñan-Lison, Carmen
Blaya-Cánovas, Jose L.
López-Tejada, Araceli
Ávalos-Moreno, Marta
Navarro-Ocón, Alba
Cara, Francisca E.
González-González, Adrián
Lorente, Jose A.
Marchal, Juan A.
Granados-Principal, Sergio

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI
Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Breast cancer is the most frequent cancer and the leading cause of cancer death in women. Oxidative stress and the generation of reactive oxygen species (ROS) have been related to cancer progression. Compared to their normal counterparts, tumor cells show higher ROS levels and tight regulation of REDOX homeostasis to maintain a low degree of oxidative stress. Traditionally antioxidants have been extensively investigated to counteract breast carcinogenesis and tumor progression as chemopreventive agents; however, there is growing evidence indicating their potential as adjuvants for the treatment of breast cancer. Aimed to elucidate whether antioxidants could be a reality in the management of breast cancer patients, this review focuses on the latest investigations regarding the ambivalent role of antioxidants in the development of breast cancer, with special attention to the results derived from clinical trials, as well as their potential use as plausible agents in combination therapy and their power to ameliorate the side effects attributed to standard therapeutics. Data retrieved herein suggest that antioxidants play an important role in breast cancer prevention and the improvement of therapeutic efficacy; nevertheless, appropriate patient stratification based on "redoxidomics" or tumor subtype is mandatory in order to define the dosage for future standardized and personalized treatments of patients.

Description

MeSH Terms

Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Protective Agents::Antioxidants
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Breast Diseases::Breast Neoplasms
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism::Oxidation-Reduction
Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Carcinogenesis
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis

DeCS Terms

CIE Terms

Keywords

Breast cancer, Antioxidants, Reactive oxygen species, Cancer stem cells, Clinical trials, Adjuvant therapy, Cancer prevention, Neoplasias de la mama, Antioxidantes, Especies reactivas de oxígeno, Células madre neoplásicas, Ensayos clínicos como asunto

Citation

Griñan-Lison C, Blaya-Cánovas JL, López-Tejada A, Ávalos-Moreno M, Navarro-Ocón A, Cara FE, et al. Antioxidants for the Treatment of Breast Cancer: Are We There Yet? Antioxidants. 2021 Jan 31;10(2):205