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Cancer genes hypermethylated in human embryonic stem cells.

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dc.contributor.authorCalvanese, Vincenzo
dc.contributor.authorHorrillo, Angelica
dc.contributor.authorHmadcha, Abdelkrim
dc.contributor.authorSuarez-Alvarez, Beatriz
dc.contributor.authorFernandez, Agustín F
dc.contributor.authorLara, Ester
dc.contributor.authorCasado, Sara
dc.contributor.authorMenendez, Pablo
dc.contributor.authorBueno, Clara
dc.contributor.authorGarcia-Castro, Javier
dc.contributor.authorRubio, Ruth
dc.contributor.authorLapunzina, Pablo
dc.contributor.authorAlaminos, Miguel
dc.contributor.authorBorghese, Lodovica
dc.contributor.authorTerstegge, Stefanie
dc.contributor.authorHarrison, Neil J
dc.contributor.authorMoore, Harry D
dc.contributor.authorBrüstle, Oliver
dc.contributor.authorLopez-Larrea, Carlos
dc.contributor.authorAndrews, Peter W
dc.contributor.authorSoria, Bernat
dc.contributor.authorEsteller, Manel
dc.contributor.authorFraga, Mario F
dc.contributor.authoraffiliation[Calvanese,V; Fernandez,AF; Casado,S; Esteller,M; Fraga,MF] Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [Horrillo,A; Hmadcha,A] Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Seville, Spain. [Suarez-Álvarez,B; Lopez-Larrea,C; Soria,B] Unidad de Histocompatibilidad, HUCA, Oviedo, Spain. [Fernandez,AF; Esteller,M] Cancer Epigenetics and Biology Program (PEBC), Catalan Institute of Oncology (ICO), Barcelona, Spain. [Menendez,P; Bueno,C; Garcia-Castro,J; Rubio,R] Andalusian Stem Cell Bank (BACM)/University of Granada, Instituto de Investigaciones Biomédicas, Parque Tecnológico de la Salud, Granada, Spain. [Lapunzina,P] S. de Genética Médica y Molecular, Hospital Universitario La Paz, Madrid y CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain. [Alaminos,M] Department of Histology, University of Granada, Granada, Spain. [Borghese,L; Terstegge,S; Brüstle,O] Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany. [Harrison,NJ; Moore,HD; Andrews,PW] Centre for Stem Cell Biology and the Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom. [Fraga,MF] Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spaines
dc.contributor.funderThis work was primarily supported by the European Union (LSHG-CT-2006-018739; ESTOOLS). MFF is funded by the Spanish Ramon & Cajal Programme and the Health Department of the Spanish Government (PI061267). The Cancer Epigenetics group at the CNIO is supported by the Health (FIS01-04) and Education and Science (I+D+I MCYT08-03, FU2004-02073/BMC and Consolider MEC09-05) Departments of the Spanish Government, the European Grant TRANSFOG LSHC-CT-2004-503438, and the Spanish Association Against Cancer (AECC). VC is a recipient of a Fellowship from the FPU Spanish Research Programme. CLL and BSA are supported by the Health Department of the Spanish Government (PI051707). The BACM is supported by the Consejería de Salud de la Junta de Andalucía (0029 and, 0030/2006 to PM) and, the Spanish Ministry of Health to PM (FIS PI070026). CB is supported by the International Jose Carreras Foundation against Leukemia (EDThomas-05) and the ISCIII (FIS 3+3 contract). The Institute of Reconstructive Neurobiology received additional funding from the DFG and the Hertie Foundation. BS, AbH and AnH are supported by the Fundación Progreso y Salud and Instituto de Salud Carlos III-Red Española de Terapia Celular (RD06/0010/0025 ). PWA, NH and HDM are also supported by the MRC.
dc.date.accessioned2013-02-13T08:14:00Z
dc.date.available2013-02-13T08:14:00Z
dc.date.issued2008-09-29
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractDevelopmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA hypermethylation. Our results indicate a role for DNA methylation in the control of gene expression in human stem cells and suggest that, for genes repressed by promoter hypermethylation in stem cells in vivo, the aberrant process in cancer could be understood as a defect in establishing an unmethylated promoter during differentiation, rather than as an anomalous process of de novo hypermethylation.es
dc.description.versionYeses
dc.identifier.citationCalvanese V, Horrillo A, Hmadcha A, Suarez-Alvarez B, Fernandez AF, Lara E, et al. Cancer genes hypermethylated in human embryonic stem cells. PLoS ONE; 3(9):e3294es
dc.identifier.doi10.1371/journal.pone.0003294
dc.identifier.essn1932-6203
dc.identifier.pmcPMC2546447
dc.identifier.pmid18820729
dc.identifier.urihttp://hdl.handle.net/10668/765
dc.journal.titlePloS One
dc.language.isoen
dc.publisherPublic library of Sciencees
dc.relation.publisherversionhttp://www.plosone.org/article/authors/info%3Adoi%2F10.1371%2Fjournal.pone.0003294es
dc.rights.accessRightsopen access
dc.subjectChromatines
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::L Cells (Cell Line)es
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus::Cell Nucleus Structures::Intranuclear Space::Chromosomes::Chromosome Structures::Chromatines
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylationes
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cells::Embryonic Stem Cellses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Developmentales
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic::Gene Silencinges
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Neoplasmes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Neoplasmes
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::HeLa Cellses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Diseases::Neoplasmses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Componentses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time Factorses
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::U937 Cellses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiationes
dc.titleCancer genes hypermethylated in human embryonic stem cells.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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