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BAFF, APRIL Y BAFFR: DIFFERENTIAL BIOMARKERS BETWEEN IGA VASCULITIS AND IGA NEPHROPATHY?

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dc.contributor.authorPrieto-Pena, D.
dc.contributor.authorGenre, F.
dc.contributor.authorMartinez, S. Remuzgo
dc.contributor.authorPulito-Cueto, V.
dc.contributor.authorAtienza-Mateo, B.
dc.contributor.authorSevilla, B.
dc.contributor.authorLlorca, J.
dc.contributor.authorOrtego, N.
dc.contributor.authorLeonardo, M.
dc.contributor.authorPenalba, A.
dc.contributor.authorMartin-Penagos, L.
dc.contributor.authorFillloy, J. A. Miranda
dc.contributor.authorNarvaez, J.
dc.contributor.authorMontero, L. Caminal
dc.contributor.authorCollado, P.
dc.contributor.authorFernandez-Nebro, A.
dc.contributor.authorDiaz-Cordoves, G.
dc.contributor.authorCigarran, S.
dc.contributor.authorCalvino, J.
dc.contributor.authorCobelo, C.
dc.contributor.authorDe-Argila, D.
dc.contributor.authorVicente-Rabaneda, E. F.
dc.contributor.authorRubio-Romero, E.
dc.contributor.authorLuque, M. Leon
dc.contributor.authorBlanco-Madrigal, J. M.
dc.contributor.authorGalindez-Agirregoikoa, E.
dc.contributor.authorGualillo, O.
dc.contributor.authorIbanez, J. Martin
dc.contributor.authorCastaneda, S.
dc.contributor.authorBlanco, R.
dc.contributor.authorGonzalez-Gay, M. A.
dc.contributor.authorLopez-Mejias, R.
dc.contributor.authoraffiliation[Prieto-Pena, D.] Hosp Univ Marques Valdecilla, Div Rheumatol, IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst, Santander, Spain
dc.contributor.authoraffiliation[Genre, F.] Hosp Univ Marques Valdecilla, Div Rheumatol, IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst, Santander, Spain
dc.contributor.authoraffiliation[Martinez, S. Remuzgo] Hosp Univ Marques Valdecilla, Div Rheumatol, IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst, Santander, Spain
dc.contributor.authoraffiliation[Pulito-Cueto, V.] Hosp Univ Marques Valdecilla, Div Rheumatol, IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst, Santander, Spain
dc.contributor.authoraffiliation[Atienza-Mateo, B.] Hosp Univ Marques Valdecilla, Div Rheumatol, IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst, Santander, Spain
dc.contributor.authoraffiliation[Ortego, N.] Hosp Univ Marques Valdecilla, Div Rheumatol, IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst, Santander, Spain
dc.contributor.authoraffiliation[Blanco, R.] Hosp Univ Marques Valdecilla, Div Rheumatol, IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst, Santander, Spain
dc.contributor.authoraffiliation[Lopez-Mejias, R.] Hosp Univ Marques Valdecilla, Div Rheumatol, IDIVAL, Res Grp Genet Epidemiol & Atherosclerosis Syst, Santander, Spain
dc.contributor.authoraffiliation[Sevilla, B.] Hosp Univ San Cecilio, Div Pediat, Granada, Spain
dc.contributor.authoraffiliation[Llorca, J.] Univ Cantabria, Sch Med, Dept Epidemiol & Computat Biol, Santander, Spain
dc.contributor.authoraffiliation[Llorca, J.] Univ Cantabria, CIBER Epidemiol Salud Publ CIBERESP, Santander, Spain
dc.contributor.authoraffiliation[Ortego, N.] Univ Granada, Dept Med, Granada, Spain
dc.contributor.authoraffiliation[Leonardo, M.] Hosp Univ Marques Valdecilla, Div Pediat, Santander, Spain
dc.contributor.authoraffiliation[Penalba, A.] Hosp Univ Marques Valdecilla, Div Pediat, Santander, Spain
dc.contributor.authoraffiliation[Martin-Penagos, L.] Hosp Univ Marques Valdecilla, Div Nephrol, Santander, Spain
dc.contributor.authoraffiliation[Fillloy, J. A. Miranda] Hosp Univ Lucus Augusti, Div Rheumatol, Lugo, Spain
dc.contributor.authoraffiliation[Narvaez, J.] Hosp Univ Bellvitge, Div Rheumatol, Barcelona, Spain
dc.contributor.authoraffiliation[Montero, L. Caminal] Hosp Univ Cent Asturias, Div Rheumatol, Oviedo, Spain
dc.contributor.authoraffiliation[Collado, P.] Hosp Univ Severo Ochoa, Div Rheumatol, Madrid, Spain
dc.contributor.authoraffiliation[Fernandez-Nebro, A.] Hosp Reg Univ Carlos Haya, Div Rheumatol, Malaga, Spain
dc.contributor.authoraffiliation[Diaz-Cordoves, G.] Hosp Reg Univ Carlos Haya, Div Rheumatol, Malaga, Spain
dc.contributor.authoraffiliation[Cigarran, S.] Hosp Costa Burela, Div Nephrol, Lugo, Spain
dc.contributor.authoraffiliation[Calvino, J.] Hosp Univ Lucus Augusti, Div Nephrol, Lugo, Spain
dc.contributor.authoraffiliation[Cobelo, C.] Hosp Univ Lucus Augusti, Div Nephrol, Lugo, Spain
dc.contributor.authoraffiliation[De Argila, D.] Hosp Univ La Princesa, Dept Dermatol, Madrid, Spain
dc.contributor.authoraffiliation[Vicente-Rabaneda, E. F.] Hosp Univ La Princesa, Div Rheumatol, Madrid, Spain
dc.contributor.authoraffiliation[Rubio-Romero, E.] Hosp Univ Virgen Rocio, Div Rheumatol, Seville, Spain
dc.contributor.authoraffiliation[Luque, M. Leon] Hosp Univ Virgen Rocio, Div Rheumatol, Seville, Spain
dc.contributor.authoraffiliation[Blanco-Madrigal, J. M.] Hosp Univ Basurto, Div Rheumatol, Bilbao, Spain
dc.contributor.authoraffiliation[Galindez-Agirregoikoa, E.] Hosp Univ Basurto, Div Rheumatol, Bilbao, Spain
dc.contributor.authoraffiliation[Gualillo, O.] Hosp Clin Univ Santiago, SERGAS Serv Galego Saude, Santiago De Compostela, Spain
dc.contributor.authoraffiliation[Gualillo, O.] IDIS Inst Invest Sanitaria Santiago, NEIRID Lab Neuroendocrine Interact Rheumatol & In, Res Lab 9, Santiago De Compostela, Spain
dc.contributor.authoraffiliation[Ibanez, J. Martin] PTS Granada, CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, Spain
dc.contributor.authoraffiliation[Castaneda, S.] PTS Granada, CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, Spain
dc.contributor.authoraffiliation[Gonzalez-Gay, M. A.] Univ Cantabria, Dept Med & Psychiat, Santander, Spain
dc.contributor.authoraffiliation[Gonzalez-Gay, M. A.] Hosp Univ Marques Valdecilla, Rheumatol Div, Res Grp Genet Epidemiol & Atherosclerosis Syst, IDIVAL, Santander, Spain
dc.contributor.authoraffiliation[Gonzalez-Gay, M. A.] Sch Physiol, Cardiovasc Pathophysiol & Genom Res Unit, Fac Hlth Sci, Johannesburg, Spain
dc.contributor.funderEuropean Regional Development Fund (ERDF)
dc.contributor.funderFondo de Investigaciones Sanitarias from 'Instituto de Salud Carlos III' (ISCIII, Health Ministry, Spain)
dc.contributor.funderRio Hortega programme fellowship from the ISCIII
dc.contributor.funderEuropean Social Fund (ESF, 'Investing in your future')
dc.contributor.funderRETICS Program - ERDF
dc.contributor.funderIDIVAL
dc.contributor.funderMiguel Servet type II programme fellowship from the ISCIII
dc.date.accessioned2023-05-03T13:30:06Z
dc.date.available2023-05-03T13:30:06Z
dc.date.issued2022-06-01
dc.description.abstractBackground: IgA vasculitis (IgAV) and IgA nephropathy (IgAN) are inflammatory conditions [1, 2], that share pathogenic mechanisms [1], in which B-lymphocytes are described as key cells implicated in these processes. BAFF, APRIL, and BAFF-R are cytokines implicated in the development of B-lymphocytes [3, 4] and in autoimmune processes [5, 6]. In this regard, an influence of BAFF, APRIL, and BAFFR polymorphisms was observed on several immune-mediated conditions, with BAFF GCTGT>A being a shared insertion-deletion variant for inflammatory conditions [7, 8]. Objectives: To determine whether BAFF, APRIL, and BAFFR could be used as differential biomarkers between IgAV and IgAN. Methods: BAFF rs374039502 (which colocalizes with BAFF GCTGT>A), two tag variants within APRIL (rs11552708 and rs6608), and two tag variants within BAFFR (rs7290134 and rs77874543) were genotyped in 394 Caucasian IgAV patients, 95 patients with IgAN, and 832 matched healthy controls.
dc.description.sponsorshipThis study was supported by the European Regional Development Fund (ERDF) and “Fondo de Investigaciones Sanitarias” (grant PI18/00042 and PI21/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). DP-P is a recipient of a Río Hortega programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, 'Investing in your future') [grant number CM20/00006]; SR-M is supported by funds of the RETICS Program co-funded by ERDF [grant number RD16/0012/0009]; VP-C is supported by a pre-doctoral grant from IDIVAL [grant number PREVAL 18/01]; RL-M is a recipient of a Miguel Servet type II programme fellowship from the ISCIII, co-funded by ESF 'Investing in your future' [grant number CPII21/00004].
dc.description.versionNo
dc.identifier.citationPrieto-Peña, D., Genre, F., Martinez, S. R., Pulito-Cueto, V., Atienza-Mateo, B., Sevilla, B., et al. AB0146 BAFF, APRIL y BAFFR: DIFFERENTIAL BIOMARKERS BETWEEN IGA VASCULITIS AND IGA NEPHROPATHY? Annals Of The Rheumatic Diseases, 81(Suppl 1), 1203-1204. https://doi.org/10.1136/annrheumdis-2022-eular.425
dc.identifier.doi10.1136/annrheumdis-2022-eular.425
dc.identifier.essn1468-2060
dc.identifier.issn0003-4967
dc.identifier.unpaywallURLhttps://ard.bmj.com/content/annrheumdis/81/Suppl_1/1203.full.pdf
dc.identifier.urihttp://hdl.handle.net/10668/20051
dc.identifier.wosID850279005004
dc.issue.number1
dc.journal.titleAnnals of the rheumatic diseases
dc.journal.titleabbreviationAnn. rheum. dis.
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Regional de Málaga
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number1203-1204
dc.provenanceRealizada la curación de contenido 12/03/2025
dc.publisherBMJ Group
dc.relation.projectIDPI18/00042
dc.relation.projectIDPI21/00042
dc.relation.projectIDCM20/00006
dc.relation.projectIDRD16/0012/0009
dc.relation.projectIDCPII21/00004
dc.relation.publisherversionhttps://ard.bmj.com/content/81/Suppl_1/1203
dc.rights.accessRightsRestricted Access
dc.subjectB-Lymphocytes
dc.subjectCells
dc.subjectGlomerulonephritis, IGA
dc.subjectCytokines
dc.subject.decsLinfocitos B
dc.subject.decsGlomerulonefritis por IGA
dc.subject.decsVasculitis por IgA
dc.subject.decsBiomarcadores
dc.subject.decsCitocinas
dc.subject.meshGlomerulonephritis, IGA
dc.subject.meshIgA Vasculitis
dc.subject.meshCytokines
dc.subject.meshWhite People
dc.titleBAFF, APRIL Y BAFFR: DIFFERENTIAL BIOMARKERS BETWEEN IGA VASCULITIS AND IGA NEPHROPATHY?
dc.typeconference output
dc.type.hasVersionVoR
dc.volume.number81
dc.wostypeMeeting Abstract
dspace.entity.typePublication

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