Publication: IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients.
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Identifiers
Date
2019-01-09
Authors
Deira, Javier
Suárez, Miguel A
López, Francisca
García-Cabrera, Emilio
Gascón, Antonio
Torregrosa, Eduardo
García, Giannina E
Huertas, Jorge
de la Flor, Jose C
Puello, Suleya
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Abstract
Most people who make the transition to renal replacement therapy (RRT) are treated with a fixed dose thrice-weekly hemodialysis réegimen, without considering their residual kidney function (RKF). Recent papers inform us that incremental hemodialysis is associated with preservation of RKF, whenever compared with conventional hemodialysis. The objective of the present controlled randomized trial (RCT) is to determine if start HD with one sessions per week (1-Wk/HD), it is associated with better patient survival and other safety parameters. IHDIP is a multicenter RCT experimental open trial. It is randomized in a 1:1 ratio and controlled through usual clinical practice, with a low intervention level and non-commercial. It includes 152 incident patients older than 18 years, with a RRF of ≥4 ml/min/1.73 m2, measured by renal clearance of urea (KrU). The intervention group includes 76 patients who will start with incremental HD (1-Wk/HD). The control group includes 76 patients who will start with thrice-weekly hemodialysis régimen. The primary outcome is assessing the survival rate, while the secondary outcomes are the morbidity rate, the clinical parameters, the quality of life and the efficiency. This study will enable to know the number of sessions a patient should receive when starting HD, depending on his RRF. The potentially important clinical and financial implications of incremental hemodialysis warrant this RCT. U.S. National Institutes of Health, ClinicalTrials.gov . Number: NCT03239808 , completed 13/04/2017. Foundation for Training and Research of Health Professionals of Extremadura.
Description
MeSH Terms
Creatinine
Humans
Kidney
Multicenter Studies as Topic
Outcome Assessment, Health Care
Prospective Studies
Randomized Controlled Trials as Topic
Renal Dialysis
Urea
Humans
Kidney
Multicenter Studies as Topic
Outcome Assessment, Health Care
Prospective Studies
Randomized Controlled Trials as Topic
Renal Dialysis
Urea
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CIE Terms
Keywords
Incremental haemodialysis progressive hemodialysis, Once-weekly haemodialysis, Randomized clinical trial, Twice-weekly haemodialysis