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Insights on the health benefits of the bioactive compounds of coffee silverskin extract

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dc.contributor.authorFernandez-Gomez, Beatriz
dc.contributor.authorLezama, Adriana
dc.contributor.authorAmigo-Benavent, Miryam
dc.contributor.authorUllate, Monica
dc.contributor.authorHerrero, Miguel
dc.contributor.authorAngeles Martin, Maria
dc.contributor.authorDolores Mesa, Maria
dc.contributor.authorDolores del Castillo, Maria
dc.contributor.authoraffiliation[Fernandez-Gomez, Beatriz] CSIC UAM, Dept Food Anal & Bioact, Food Sci Res Inst, CIAL, C Nicolas Cabrera 9,Campus Univ Autonoma Madrid, Madrid 28049, Spain
dc.contributor.authoraffiliation[Lezama, Adriana] CSIC UAM, Dept Food Anal & Bioact, Food Sci Res Inst, CIAL, C Nicolas Cabrera 9,Campus Univ Autonoma Madrid, Madrid 28049, Spain
dc.contributor.authoraffiliation[Ullate, Monica] CSIC UAM, Dept Food Anal & Bioact, Food Sci Res Inst, CIAL, C Nicolas Cabrera 9,Campus Univ Autonoma Madrid, Madrid 28049, Spain
dc.contributor.authoraffiliation[Herrero, Miguel] CSIC UAM, Dept Food Anal & Bioact, Food Sci Res Inst, CIAL, C Nicolas Cabrera 9,Campus Univ Autonoma Madrid, Madrid 28049, Spain
dc.contributor.authoraffiliation[Dolores del Castillo, Maria] CSIC UAM, Dept Food Anal & Bioact, Food Sci Res Inst, CIAL, C Nicolas Cabrera 9,Campus Univ Autonoma Madrid, Madrid 28049, Spain
dc.contributor.authoraffiliation[Amigo-Benavent, Miryam] Inst Food Sci Technol & Nutr ICTAN CSIC, Dept Nutr & Metab, Madrid 28040, Spain
dc.contributor.authoraffiliation[Angeles Martin, Maria] Inst Food Sci Technol & Nutr ICTAN CSIC, Dept Nutr & Metab, Madrid 28040, Spain
dc.contributor.authoraffiliation[Amigo-Benavent, Miryam] Univ Limerick, Ctr Intervent Inflammat Infect & Immun 4i, Limerick, Ireland
dc.contributor.authoraffiliation[Angeles Martin, Maria] Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid 28029, Spain
dc.contributor.authoraffiliation[Dolores Mesa, Maria] Univ Granada, Inst Nutr & Food Technol Jose Mataix, Biomed Res Ctr CIBM, Avd Conocimiento S-N, Granada 18100, Spain
dc.contributor.authoraffiliation[Dolores Mesa, Maria] Inst Invest Biosanitaria IBS, Granada, Spain
dc.contributor.funderSUSCOFFEE
dc.contributor.funderSAMID
dc.contributor.funderMINECO
dc.contributor.funderPN I+D+I (Spain)
dc.contributor.funderISCIII-Sub-Directorate General for Research Assessment and Promotion
dc.contributor.funderEuropean Regional Development Fund (ERDF)
dc.date.accessioned2023-02-12T02:20:57Z
dc.date.available2023-02-12T02:20:57Z
dc.date.issued2016-07-04
dc.description.abstractThe bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.
dc.description.versionSi
dc.identifier.citationBeatriz Fernandez-Gomez, Adriana Lezama, Miryam Amigo-Benavent, Mónica Ullate, Miguel Herrero, María Ángeles Martín, et al. Insights on the health benefits of the bioactive compounds of coffee silverskin extract, Journal of Functional Foods, Volume 25, 2016, Pages 197-207,
dc.identifier.doi10.1016/j.jff.2016.06.001
dc.identifier.issn1756-4646
dc.identifier.unpaywallURLhttps://digital.csic.es/bitstream/10261/140285/4/Insightscoffeesilverskin.pdf
dc.identifier.urihttp://hdl.handle.net/10668/18815
dc.identifier.wosID381234200017
dc.journal.titleJournal of functional foods
dc.journal.titleabbreviationJ. funct. food.
dc.language.isoen
dc.organizationInstituto de Investigación Biosanitaria ibs. GRANADA
dc.page.number197-207
dc.provenanceRealizada la curación de contenido 12/08/2024
dc.publisherElsevier BV
dc.relation.publisherversionsciencedirect.com/science/article/abs/pii/S1756464616301414
dc.rights.accessRightsRestricted Access
dc.subjectCoffee silverskin
dc.subjectChlorogenic acid
dc.subjectBioaccessibility
dc.subjectMetabolism
dc.subjectType 2 diabetes
dc.subjectIn-vitro
dc.subjectChlorogenic acid
dc.subjectAntioxidant capacity
dc.subjectOxidative stress
dc.subjectGastrointestinal digestion
dc.subjectCaffeine
dc.subjectStreptozotocin
dc.subjectBioaccessibility
dc.subjectCells
dc.subjectRats
dc.subject.decsAnimales
dc.subject.decsAntioxidantes
dc.subject.decsConcentración de iones de Hidrógeno
dc.subject.decsDiabetes Mellitus tipo 2
dc.subject.decsDigestión
dc.subject.decsDisponibilidad biológica
dc.subject.decsNiacinamida
dc.subject.decsProteínas
dc.subject.decsPáncreas
dc.subject.decsTracto gastrointestinal
dc.subject.meshAnimals
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshAntioxidants
dc.subject.meshBiological Availability
dc.subject.meshPancreas
dc.subject.meshProteins
dc.subject.meshGastrointestinal Tract
dc.subject.meshHydrogen-Ion Concentration
dc.subject.meshNiacinamide
dc.subject.meshDigestion
dc.titleInsights on the health benefits of the bioactive compounds of coffee silverskin extract
dc.typeresearch article
dc.type.hasVersionSMUR
dc.volume.number25
dc.wostypeArticle
dspace.entity.typePublication

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