Publication:
Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study.

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Date

2019-05-21

Authors

Perez-Belmonte, Luis M
Osuna-Sanchez, Julio
Millan-Gomez, Mercedes
Lopez-Carmona, Maria D
Gomez-Doblas, Juan J
Cobos-Palacios, Lidia
Sanz-Canovas, Jaime
Barbancho, Miguel A
Lara, Jose P
Jimenez-Navarro, Manuel

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Taylor & Francis
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Abstract

Introduction: The use of dipeptidyl peptidase-4 inhibitors in hospitalized patients is an area of active research. We aimed to compare the efficacy and the safety of the basal-bolus insulin regimen versus linagliptin-basal insulin in non-critically ill non-cardiac surgery patients in a real-world setting. Methods: We enrolled patients with type 2 diabetes hospitalized in non-cardiac surgery departments with admission glycated haemoglobin level 200 mg/dL (p = .199), and treatment failures (p = .395). Total daily insulin and number of daily insulin injections were lower in the linagliptin-basal group (both p p < .001). Patients on linagliptin-basal insulin had fewer hypoglycaemicevents (blood glucose < 70 mg/dL) (p < .001).Conclusion: For type 2 diabetes surgery patients with mild to moderate hyperglycaemia with-out pre-hospitalization injectable therapies, linagliptin-basal insulin was an effective, safe alterna-tive with fewer hypoglycaemic events in real-world practice.

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MeSH Terms

Aged
Blood Glucose
Diabetes Mellitus, Type 2
Dipeptidyl-Peptidase IV Inhibitors
Drug Therapy, Combination
Female
Glycated Hemoglobin
Hospitalization
Humans
Hypoglycemia
Hypoglycemic Agents
Insulin
Linagliptin
Male
Middle Aged
Safety
Spain
Treatment Failure
Treatment Outcome

DeCS Terms

Insulina
Linagliptina
Diabetes Mellitus Tipo 2
Cirugía Torácica
Glucemia
Insuficiencia del Tratamiento

CIE Terms

Keywords

Diabetes mellitus, Inpatient hyperglycaemia, Linagliptin, Non-cardiac surgery

Citation

Pérez-Belmonte LM, Osuna-Sánchez J, Millán-Gómez M, López-Carmona MD, Gómez-Doblas JJ, Cobos-Palacios L, et al. Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study. Ann Med. 2019 May-Jun;51(3-4):252-261