Publication:
Increased Presentation of Diabetic Ketoacidosis and Changes in Age and Month of Type 1 Diabetes at Onset during the COVID-19 Pandemic in Spain.

dc.contributor.authorLeiva-Gea, Isabel
dc.contributor.authorFernández, Cristina Antúnez
dc.contributor.authorCardona-Hernandez, Roque
dc.contributor.authorLozano, Marta Ferrer
dc.contributor.authorBahíllo-Curieses, Pilar
dc.contributor.authorArroyo-Díez, Javier
dc.contributor.authorLeón, María Clemente
dc.contributor.authorMartín-Frías, Maria
dc.contributor.authorBarreiro, Santiago Conde
dc.contributor.authorDelgado, Andrés Mingorance
dc.contributor.authorSánchez, Jacobo Pérez
dc.contributor.authorDiabetes Group of the Spanish Pediatric Endocrinology Society (SEEP)
dc.date.accessioned2023-05-03T14:08:52Z
dc.date.available2023-05-03T14:08:52Z
dc.date.issued2022-07-26
dc.description.abstractObjective: To assess the impact of the COVID-19 pandemic and lockdown measures on the presenting characteristics (age at diagnosis, severity, monthly distribution) of newly diagnosed type 1 diabetes in Spanish children. Research DesignandMethods: An ambispective observational multicenter study was conducted in nine Spanish tertiary-level hospitals between January 2015 and March 2021. Inclusion criteria: new cases of type 1 diabetes in children (0-14 years) recording age, sex, date of diagnosis, presence of diabetic ketoacidosis (DKA) at onset, and severity of DKA. Data were compared before and during the pandemic. Results: We registered 1444 new cases of type 1 diabetes in children: 1085 in the pre-pandemic period (2015-2019) and 359 during the pandemic (2020-March 2021). There was a significant increase in the group aged ≤4 years in the pandemic period (chi-squared = 10.986, df 2, p = 0.0041). In 2020-2021, cases of DKA increased significantly by 12% (95% CI: 7.2-20.4%), with a higher percentage of moderate and severe DKA, although this increase was not significant. In 2020, there was a sharp decrease in the number of cases in March, with a progressive increase from May through November, higher than in the same months of the period 2015-2019, highlighting the increase in the number of cases in June, September, and November. The first three months of 2021 showed a different trend to that observed both in the years 2015-2019 and in 2020, with a marked increase in the number of cases. Conclusions: A change in monthly distribution was described, with an increase in DKA at onset of type 1 diabetes. No differences were found in severity, although there were differences in the age distribution, with an increase in the number of cases in children under 4 years of age.
dc.identifier.doi10.3390/jcm11154338
dc.identifier.issn2077-0383
dc.identifier.pmcPMC9369057
dc.identifier.pmid35893428
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369057/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2077-0383/11/15/4338/pdf?version=1659062306
dc.identifier.urihttp://hdl.handle.net/10668/21326
dc.issue.number15
dc.journal.titleJournal of clinical medicine
dc.journal.titleabbreviationJ Clin Med
dc.language.isoen
dc.organizationÁrea de Gestión Sanitaria Campo de Gibraltar Oeste
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationAGS - Campo de Gibraltar Oeste
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectDKA
dc.subjectdiabetes onset
dc.subjecttype 1 diabetes
dc.titleIncreased Presentation of Diabetic Ketoacidosis and Changes in Age and Month of Type 1 Diabetes at Onset during the COVID-19 Pandemic in Spain.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication

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