Publication:
Analyses of hair and salivary cortisol for evaluating hypothalamic-pituitary-adrenal axis activation in patients with autoimmune disease.

dc.contributor.authorMontero-López, Eva
dc.contributor.authorSantos-Ruiz, Ana
dc.contributor.authorGonzález, Raquel
dc.contributor.authorNavarrete-Navarrete, Nuria
dc.contributor.authorOrtego-Centeno, Norberto
dc.contributor.authorMartínez-Augustín, Olga
dc.contributor.authorRodríguez-Blázquez, Manuel
dc.contributor.authorPeralta-Ramírez, María Isabel
dc.date.accessioned2023-01-25T09:51:24Z
dc.date.available2023-01-25T09:51:24Z
dc.date.issued2017-08-30
dc.description.abstractAlthough many studies have shown that patients with autoimmune disease present a hypoactive hypothalamic-pituitary-adrenal axis (HPA), controversial results have been described. Our objective was to study HPA axis activity in women with autoimmune disease compared to healthy women. Therefore, we analyzed salivary cortisol over the course of a day, and hair cortisol concentrations from the three preceding months, from 65 women divided into two groups: healthy women (n = 30), with a mean age of 44.70 ± 11.65 years; and women with autoimmune disease (n = 35), with a mean age of 48.26 ± 9.04 years. The latter group comprises women with systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and systemic sclerosis (SSc). Perceived stress and psychopathological symptomatology were also evaluated. Autoimmune disease group scored higher on the somatization subscale SCL-90-R and lower on the anxiety subscale than the control group. Regarding HPA axis activation, the area under curve for cortisol levels during the day was higher for the autoimmune disease group. In addition, higher cortisol levels in hair were found in the group with autoimmune disease. Our findings show greater short and long-term HPA axis activity in women with autoimmune disease than in healthy women.
dc.identifier.doi10.1080/10253890.2017.1369524
dc.identifier.essn1607-8888
dc.identifier.pmid28853298
dc.identifier.unpaywallURLhttps://rua.ua.es/dspace/bitstream/10045/72990/5/2017_Montero-Lopez_etal_Stress_accepted.pdf
dc.identifier.urihttp://hdl.handle.net/10668/11542
dc.issue.number6
dc.journal.titleStress (Amsterdam, Netherlands)
dc.journal.titleabbreviationStress
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationArea de Gestión Sanitaria Norte de Jaén
dc.organizationAGS - Norte de Jaén
dc.page.number541-548
dc.pubmedtypeJournal Article
dc.rights.accessRightsopen access
dc.subjectHPA axis
dc.subjectSjögren’s syndrome
dc.subjectStress
dc.subjectcortisol
dc.subjectsystemic lupus erythematosus
dc.subjectsystemic sclerosis
dc.subject.meshAdult
dc.subject.meshAutoimmune Diseases
dc.subject.meshCase-Control Studies
dc.subject.meshFemale
dc.subject.meshHair
dc.subject.meshHumans
dc.subject.meshHydrocortisone
dc.subject.meshHypothalamo-Hypophyseal System
dc.subject.meshLupus Erythematosus, Systemic
dc.subject.meshMiddle Aged
dc.subject.meshPituitary-Adrenal System
dc.subject.meshSaliva
dc.subject.meshScleroderma, Systemic
dc.subject.meshSjogren's Syndrome
dc.subject.meshStress, Psychological
dc.titleAnalyses of hair and salivary cortisol for evaluating hypothalamic-pituitary-adrenal axis activation in patients with autoimmune disease.
dc.typeresearch article
dc.type.hasVersionSMUR
dc.volume.number20
dspace.entity.typePublication

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