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Efficacy of beta-Lactam/beta-Lactamase Inhibitor Combinations for the Treatment of Bloodstream Infection Due to Extended-Spectrum-beta-Lactamase-Producing Enterobacteriaceae in Hematological Patients with Neutropenia

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dc.contributor.authorGudiol, Carlota
dc.contributor.authorRoyo-Cebrecos, Cristina
dc.contributor.authorAbdala, Edson
dc.contributor.authorAkova, Murat
dc.contributor.authorAlvarez, Rocio
dc.contributor.authorMaestro-de la Calle, Guillermo
dc.contributor.authorCano, Angela
dc.contributor.authorCervera, Carlos
dc.contributor.authorClemente, Wanessa T.
dc.contributor.authorMartin-Davila, Pilar
dc.contributor.authorFreifeld, Alison
dc.contributor.authorGomez, Lucia
dc.contributor.authorGottlieb, Thomas
dc.contributor.authorGurgui, Merce
dc.contributor.authorHerrera, Fabian
dc.contributor.authorManzur, Adriana
dc.contributor.authorMaschmeyer, Georg
dc.contributor.authorMeije, Yolanda
dc.contributor.authorMontejo, Miguel
dc.contributor.authorPeghin, Maddalena
dc.contributor.authorRodriguez-Bano, Jesus
dc.contributor.authorRuiz-Camps, Isabel
dc.contributor.authorSukiennik, Teresa C.
dc.contributor.authorTebe, Cristian
dc.contributor.authorCarratala, Jordi
dc.contributor.authoraffiliation[Gudiol, Carlota] Univ Barcelona, Bellvitge Univ Hosp, IDIBELL, Infect Dis Dept, Barcelona, Spain
dc.contributor.authoraffiliation[Royo-Cebrecos, Cristina] Univ Barcelona, Bellvitge Univ Hosp, IDIBELL, Infect Dis Dept, Barcelona, Spain
dc.contributor.authoraffiliation[Carratala, Jordi] Univ Barcelona, Bellvitge Univ Hosp, IDIBELL, Infect Dis Dept, Barcelona, Spain
dc.contributor.authoraffiliation[Gudiol, Carlota] Duran & Reynals Hosp, ICO, Barcelona, Spain
dc.contributor.authoraffiliation[Abdala, Edson] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Sao Paulo, Brazil
dc.contributor.authoraffiliation[Akova, Murat] Hacettepe Univ, Sch Med, Ankara, Turkey
dc.contributor.authoraffiliation[Alvarez, Rocio] Univ Seville, CSIC, Univ Hosp Virgen Rocio & Virgen Macarena, Inst Biomed Seville IBiS,Infect Dis Res Grp,Clin, Seville, Spain
dc.contributor.authoraffiliation[Maestro-de la Calle, Guillermo] Univ Complutense, Sch Med, Octubre Univ Hosp 12, Inst Invest Hosp Octubre 12 i 12,Infect Dis Unit, Madrid, Spain
dc.contributor.authoraffiliation[Cano, Angela] UCO, Reina Sofia Univ Hosp, IMIBIC, Cordoba, Spain
dc.contributor.authoraffiliation[Cervera, Carlos] Univ Alberta Hosp, Edmonton, AB, Canada
dc.contributor.authoraffiliation[Clemente, Wanessa T.] Univ Fed Minas Gerais, Hosp Clin, Digest Transplant Serv, Belo Horizonte, MG, Brazil
dc.contributor.authoraffiliation[Martin-Davila, Pilar] Hosp Ramon & Cajal, Infect Dis Dept, Madrid, Spain
dc.contributor.authoraffiliation[Freifeld, Alison] Univ Nebraska, Med Ctr, Internal Med Infect Dis Sect, Omaha, NE 68182 USA
dc.contributor.authoraffiliation[Gomez, Lucia] Univ Hosp Mutua Terrassa, Internal Med, Barcelona, Spain
dc.contributor.authoraffiliation[Gottlieb, Thomas] Concord Hosp, Dept Microbiol & Infect Dis, Concord, NSW, Australia
dc.contributor.authoraffiliation[Gurgui, Merce] Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Infect Dis Unit, Barcelona, Spain
dc.contributor.authoraffiliation[Gurgui, Merce] Univ Autonoma Barcelona, Inst Invest Biomed Sant Pau, Barcelona, Spain
dc.contributor.authoraffiliation[Herrera, Fabian] CEMIC, Dept Med, Infect Dis Sect, Buenos Aires, DF, Argentina
dc.contributor.authoraffiliation[Manzur, Adriana] Hosp Rawson, Infect Dis, San Juan, Argentina
dc.contributor.authoraffiliation[Maschmeyer, Georg] Charite, Med Sch, Acad Teaching Hosp, Dept Hematol Oncol & Palliat Care,Klinikum Ernst, Berlin, Germany
dc.contributor.authoraffiliation[Meije, Yolanda] Barcelona Hosp, SCIAS, Internal Med Dept, Infect Dis Unit, Barcelona, Spain
dc.contributor.authoraffiliation[Montejo, Miguel] Cruces Univ Hosp, Infect Dis Unit, Bilbao, Spain
dc.contributor.authoraffiliation[Peghin, Maddalena] Santa Maria Misericordia Univ Hosp, Infect Dis Div, Udine, Italy
dc.contributor.authoraffiliation[Rodriguez-Bano, Jesus] Univ Seville, Univ Hosp Virgen Macarena & Virgen Rocio IBiS, Dept Med, Clin Unit Infect Dis Microbiol & Prevent Med, Seville, Spain
dc.contributor.authoraffiliation[Ruiz-Camps, Isabel] Vall Hebron Univ Hosp, Infect Dis Dept, Barcelona, Spain
dc.contributor.authoraffiliation[Sukiennik, Teresa C.] Hosp Santa Casa Misericordia Porto Alegre, Porto Alegre, RS, Brazil
dc.contributor.authoraffiliation[Tebe, Cristian] Rovira & Virgili Univ, Inst Biomed Res Bellvitge, Stat Advisory Serv, Tarragona, Spain
dc.contributor.authoraffiliation[Gudiol, Carlota] Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain
dc.contributor.authoraffiliation[Royo-Cebrecos, Cristina] Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain
dc.contributor.authoraffiliation[Meije, Yolanda] Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain
dc.contributor.authoraffiliation[Montejo, Miguel] Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain
dc.contributor.authoraffiliation[Rodriguez-Bano, Jesus] Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain
dc.contributor.authoraffiliation[Ruiz-Camps, Isabel] Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain
dc.contributor.authoraffiliation[Carratala, Jordi] Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain
dc.contributor.funderESGBIS
dc.contributor.funderESGICH
dc.contributor.funderMinisterio de Economia y Competitividad, Instituto de Salud Carlos III - European Development Regional Fund "A way to achieve Europe" EDRF, Spanish Network for the Research in Infectious Diseases
dc.contributor.funderCOMBACTE-NET
dc.contributor.funderCOMBACTE-CARE
dc.contributor.funderCOMBACTE-MAGNET
dc.contributor.funderInnovative Medicines Initiative (European Union)
dc.contributor.funderInnovative Medicines Initiative (EFPIA)
dc.contributor.funderMerck
dc.contributor.funderAstellas
dc.contributor.funderNovartis
dc.contributor.funderPfizer
dc.contributor.funderMSD
dc.contributor.funderJanssen
dc.contributor.funderAstra-Zeneca
dc.contributor.groupBICAR Study Grp
dc.date.accessioned2023-02-12T02:21:36Z
dc.date.available2023-02-12T02:21:36Z
dc.date.issued2017-04-27
dc.description.abstractbeta-Lactam/beta-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum beta-lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem-sparing alternatives for the treatment of BSI due to ESBLs in these patients.
dc.description.sponsorshipWe thank the ESGBIS and the ESGICH study groups for supporting the study.This study was supported by Ministerio de Economía y Competitividad, Instituto deSalud Carlos III— cofinanced by European Development Regional Fund “A way toachieve Europe” EDRF, Spanish Network for the Research in Infectious Diseases (REIPIRD12/0015)
dc.description.versionSi
dc.identifier.citationGudiol C, Royo-Cebrecos C, Abdala E, Akova M, Álvarez R, Maestro-de la Calle G, et al. Efficacy of β-Lactam/β-Lactamase Inhibitor Combinations for the Treatment of Bloodstream Infection Due to Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in Hematological Patients with Neutropenia. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00164-17
dc.identifier.doi10.1128/AAC.00164-17
dc.identifier.essn1098-6596
dc.identifier.issn0066-4804
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc5527609?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/18998
dc.identifier.wosID406259400008
dc.issue.number8
dc.journal.titleAntimicrobial agents and chemotherapy
dc.journal.titleabbreviationAntimicrob. agents chemother.
dc.language.isoen
dc.organizationHospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationHospital Universitario Virgen Macarena
dc.publisherAmerican Society for Microbiology
dc.relation.projectIDRD12/0015
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/AAC.00164-17?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.rights.accessRightsopen access
dc.subjectESBLs
dc.subjectBloodstream infection
dc.subjectNeutropenia
dc.subjectBeta-lactam/beta-lactamase inhibitors
dc.subjectMortality
dc.subjectEscherichia-coli
dc.subject.decsCarbapenémicos
dc.subject.decsNeoplasias
dc.subject.decsPiperacilina
dc.subject.decsRiesgo
dc.subject.decsTazobactam
dc.subject.decsTerapéutica
dc.subject.decsMortalidad
dc.subject.meshKlebsiella-pneumoniae
dc.subject.meshPiperacillin-tazobactam
dc.subject.meshRisk-factors
dc.subject.meshBacteremia
dc.subject.meshCarbapenems
dc.subject.meshTherapy
dc.subject.meshMortality
dc.subject.meshOutcomes
dc.subject.meshCancer
dc.titleEfficacy of beta-Lactam/beta-Lactamase Inhibitor Combinations for the Treatment of Bloodstream Infection Due to Extended-Spectrum-beta-Lactamase-Producing Enterobacteriaceae in Hematological Patients with Neutropenia
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number61
dc.wostypeArticle
dspace.entity.typePublication

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