Publication:
Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole.

dc.contributor.authorAriza, Adriana
dc.contributor.authorGarcía-Martín, Elena
dc.contributor.authorSalas, María
dc.contributor.authorMontañez, María I
dc.contributor.authorMayorga, Cristobalina
dc.contributor.authorBlanca-Lopez, Natalia
dc.contributor.authorAndreu, Inmaculada
dc.contributor.authorPerkins, James
dc.contributor.authorBlanca, Miguel
dc.contributor.authorAgúndez, José A G
dc.contributor.authorTorres, María J
dc.date.accessioned2023-01-25T08:31:34Z
dc.date.available2023-01-25T08:31:34Z
dc.date.issued2016-03-31
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) are the most common cause of hypersensitivity reactions, with pyrazolones the most frequent drugs inducing selective reactions. Immediate selective hypersensitivity to pyrazolones is thought to be mediated by specific-IgE. Sensitivity of in vitro diagnostic tests is low and this may be due to the incomplete characterization of the structures involved. Here we investigated whether main metabolites of metamizole (dipyrone) in human could be involved in the immune response using the basophil activation test (BAT). We studied subjects with confirmed selective immediate hypersensitivity to metamizole and performed BAT with metamizole and its metabolites: 4-methylamino-antipyrine (MAA), 4-aminoantipyrine (AA), 4-acetylamino-antipyrine (AAA) and 4-formylamino-antipyrine (FAA). BAT results showed an increase of positive results from 37.5% to 62.5% using metamizole plus metabolites as compared with the BAT carried out only with the parent drug, demonstrating that metamizole metabolites have a role in the reaction and can induce specific basophil activation in patients with immediate hypersensitivity to this drug. Our findings indicate that pyrazolone metabolites are useful for improving the in vitro diagnosis of allergic reactions to metamizole.
dc.identifier.doi10.1038/srep23845
dc.identifier.essn2045-2322
dc.identifier.pmcPMC4814906
dc.identifier.pmid27030298
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814906/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/srep23845.pdf
dc.identifier.urihttp://hdl.handle.net/10668/9960
dc.journal.titleScientific reports
dc.journal.titleabbreviationSci Rep
dc.language.isoen
dc.organizationCentro Andaluz de Nanomedicina y Biotecnología-BIONAND
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationHospital Universitario Regional de Málaga
dc.organizationHospital Universitario Regional de Málaga
dc.page.number23845
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAminopyrine
dc.subject.meshAmpyrone
dc.subject.meshAnaphylaxis
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal
dc.subject.meshBasophil Degranulation Test
dc.subject.meshBasophils
dc.subject.meshBiotransformation
dc.subject.meshCase-Control Studies
dc.subject.meshDipyrone
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPilot Projects
dc.subject.meshPrimary Cell Culture
dc.titlePyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number6
dspace.entity.typePublication

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