Publication: Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives.
dc.contributor.author | Lopez-Jimenez, Auxiliadora | |
dc.contributor.author | Gallardo, Elena | |
dc.contributor.author | Espartero, Jose L | |
dc.contributor.author | Madrona, Andres | |
dc.contributor.author | Quesada, Ana R | |
dc.contributor.author | Medina, Miguel Angel | |
dc.date.accessioned | 2023-01-25T10:21:03Z | |
dc.date.available | 2023-01-25T10:21:03Z | |
dc.date.issued | 2018-08-15 | |
dc.description.abstract | Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously that hydroxytyrosol inhibits angiogenesis both in vitro and in vivo. In the present study, we evaluate the anti-angiogenic potential of five hydroxytyrosol derivatives. Three of these derivatives contain a nitro group and they exhibit a much weaker effect than hydroxytyrosol in the tubule formation assay on Matrigel and therefore were not studied further. In contrast, both hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether show more potent inhibitory effects than hydroxytyrosol in both the in vitro tubule formation assay on Matrigel and the in vivo chorioallantoic membrane assay. Additionally, these three compounds had slight pro-apoptotic effects and decreased matrix metalloproteinase-2 levels in cell extracts. | |
dc.description.version | Si | |
dc.identifier.citation | López-Jiménez A , Gallardo E , Espartero JL , Madrona A , Quesada AR , Medina MÁ . Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives. Food Funct. 2018 Aug 15;9(8):4310-4316. | |
dc.identifier.doi | 10.1039/c8fo01140k | |
dc.identifier.essn | 2042-650X | |
dc.identifier.pmid | 30040093 | |
dc.identifier.unpaywallURL | https://riuma.uma.es/xmlui/bitstream/10630/16668/1/2018-09-Food%20Function.pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/12747 | |
dc.issue.number | 8 | |
dc.journal.title | Food & function | |
dc.journal.titleabbreviation | Food Funct | |
dc.language.iso | en | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.page.number | 9 | |
dc.provenance | Realizada la curación de contenido 29/08/2025. | |
dc.publisher | Royal Society of Chemistry | |
dc.pubmedtype | Comparative Study | |
dc.pubmedtype | Journal Article | |
dc.relation.publisherversion | https://doi.org/10.1039/c8fo01140k | |
dc.rights.accessRights | Restricted Access | |
dc.subject | Hydroxytyrosol | |
dc.subject | Extra virgin olive oil | |
dc.subject | Anti-angiogenic effects | |
dc.subject | Chorioallantoic membrane assay | |
dc.subject | Hydroxytyrosyl acetate | |
dc.subject | Ethyl hydroxytyrosyl ether | |
dc.subject | Apoptosis | |
dc.subject | Nitro-derivatives of hydroxytyrosol | |
dc.subject.decs | Aceite de oliva | |
dc.subject.decs | Fenoles | |
dc.subject.decs | Tirosol | |
dc.subject.decs | Inhibidores de la angiogénesis | |
dc.subject.decs | Angiogénesis fisiológica | |
dc.subject.decs | Apoptosis | |
dc.subject.decs | Metaloproteinasa 2 de la matriz | |
dc.subject.decs | Membrana corioalantoidea | |
dc.subject.decs | Técnicas in vitro | |
dc.subject.mesh | Angiogenesis Inhibitors | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Cattle | |
dc.subject.mesh | Cell Differentiation | |
dc.subject.mesh | Cell Survival | |
dc.subject.mesh | Chick Embryo | |
dc.subject.mesh | Chorioallantoic Membrane | |
dc.subject.mesh | Endothelial Cells | |
dc.subject.mesh | Phenylethyl Alcohol | |
dc.subject.mesh | Structure-Activity Relationship | |
dc.title | Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 9 | |
dspace.entity.type | Publication |
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