Publication:
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives.

dc.contributor.authorLopez-Jimenez, Auxiliadora
dc.contributor.authorGallardo, Elena
dc.contributor.authorEspartero, Jose L
dc.contributor.authorMadrona, Andres
dc.contributor.authorQuesada, Ana R
dc.contributor.authorMedina, Miguel Angel
dc.date.accessioned2023-01-25T10:21:03Z
dc.date.available2023-01-25T10:21:03Z
dc.date.issued2018-08-15
dc.description.abstractHydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously that hydroxytyrosol inhibits angiogenesis both in vitro and in vivo. In the present study, we evaluate the anti-angiogenic potential of five hydroxytyrosol derivatives. Three of these derivatives contain a nitro group and they exhibit a much weaker effect than hydroxytyrosol in the tubule formation assay on Matrigel and therefore were not studied further. In contrast, both hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether show more potent inhibitory effects than hydroxytyrosol in both the in vitro tubule formation assay on Matrigel and the in vivo chorioallantoic membrane assay. Additionally, these three compounds had slight pro-apoptotic effects and decreased matrix metalloproteinase-2 levels in cell extracts.
dc.description.versionSi
dc.identifier.citationLópez-Jiménez A , Gallardo E , Espartero JL , Madrona A , Quesada AR , Medina MÁ . Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives. Food Funct. 2018 Aug 15;9(8):4310-4316.
dc.identifier.doi10.1039/c8fo01140k
dc.identifier.essn2042-650X
dc.identifier.pmid30040093
dc.identifier.unpaywallURLhttps://riuma.uma.es/xmlui/bitstream/10630/16668/1/2018-09-Food%20Function.pdf
dc.identifier.urihttp://hdl.handle.net/10668/12747
dc.issue.number8
dc.journal.titleFood & function
dc.journal.titleabbreviationFood Funct
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number9
dc.provenanceRealizada la curación de contenido 29/08/2025.
dc.publisherRoyal Society of Chemistry
dc.pubmedtypeComparative Study
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://doi.org/10.1039/c8fo01140k
dc.rights.accessRightsRestricted Access
dc.subjectHydroxytyrosol
dc.subjectExtra virgin olive oil
dc.subjectAnti-angiogenic effects
dc.subjectChorioallantoic membrane assay
dc.subjectHydroxytyrosyl acetate
dc.subjectEthyl hydroxytyrosyl ether
dc.subjectApoptosis
dc.subjectNitro-derivatives of hydroxytyrosol
dc.subject.decsAceite de oliva
dc.subject.decsFenoles
dc.subject.decsTirosol
dc.subject.decsInhibidores de la angiogénesis
dc.subject.decsAngiogénesis fisiológica
dc.subject.decsApoptosis
dc.subject.decsMetaloproteinasa 2 de la matriz
dc.subject.decsMembrana corioalantoidea
dc.subject.decsTécnicas in vitro
dc.subject.meshAngiogenesis Inhibitors
dc.subject.meshAnimals
dc.subject.meshCattle
dc.subject.meshCell Differentiation
dc.subject.meshCell Survival
dc.subject.meshChick Embryo
dc.subject.meshChorioallantoic Membrane
dc.subject.meshEndothelial Cells
dc.subject.meshPhenylethyl Alcohol
dc.subject.meshStructure-Activity Relationship
dc.titleComparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

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