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Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study

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dc.contributor.authorLlorente-Cantarero, Francisco Jesús
dc.contributor.authorAguilar-Gómez, Francisco Javier
dc.contributor.authorLeis, Rosaura
dc.contributor.authorBueno, Gloria
dc.contributor.authorRupérez, Azahara I.
dc.contributor.authorAnguita-Ruiz, Augusto
dc.contributor.authorVázquez-Cobela, Rocío
dc.contributor.authorMesa, María Dolores
dc.contributor.authorMoreno, Luis A.
dc.contributor.authorGil, Ángel
dc.contributor.authorAguilera, Concepción María
dc.contributor.authorGil-Campos, Mercedes
dc.contributor.authoraffiliation[Llorente-Cantarero,FJ] Department of Specific Didactics, Faculty of Education, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain. [Llorente-Cantarero,FJ; Leis,R; Bueno,G; Anguita-Ruiz,A; Vázquez-Cobela,R; Moreno,LA; Gil,A; Aguilera,CM; Gil-Campos,M] CIBEROBN, (Physiopathology of Obesity and Nutrition) Institute of Health Carlos III (ISCIII), Madrid, Spain. [Aguilar-Gomez FJ; Gil-Campos,M] Metabolism and Investigation Unit, Reina Sofía University Hospital, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain. [Leis,R; Vázquez-Cobela,R] Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, University of Santiago de Compostela, Clinic University Hospital of Santiago, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain. [Bueno,G] Pediatric Endocrinology Unit, Clinic University Hospital Lozano Blesa, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain. [Bueno,G; Rupérez,AI; Moreno,LA] GENUD Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria (IIS) Aragón, University of Zaragoza, Zaragoza, Spain. [Anguita-Ruiz,A; Mesa,MA; Gil,A; Aguilera,CM] Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, University of Granada, Armilla, Granada, Spain. [Anguita-Ruiz,A; Mesa,MA; Gil,A; Aguilera,CM] Instituto de Investigación Biosanitaria ibs Granada, 18014 Granada, Spain.
dc.contributor.funderThis research was funded by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI11/02042, PI11/02059, PI11/01425; PI16/00871, PI16/01301, PI16/01205) and RETIC (Redes temáticas de investigación cooperativa) (Red SAMID RD12/0026/0015). The authors also acknowledge Instituto de Salud Carlos III for personal funding of A.A.R: Contratos i-PFIS: doctorados IIS-empresa en ciencias y tecnologías de la salud de la convocatoria 2017 de la Acción Estratégica en Salud 2013–2016 (IFI17/00048). Á.G. was funded by the Research Plan of the Vice-Rectorate of Research and Transfer of the University of Granada, Spain This paper will be included in F.J.A. doctorate, under the “Biomedicine Program” at the University of Córdoba, Spain.
dc.date.accessioned2022-03-30T12:37:36Z
dc.date.available2022-03-30T12:37:36Z
dc.date.issued2021-02-20
dc.description.abstractThe World Health Organization has recommended performing at least 60 min a day of moderate-to-vigorous physical activity (MVPA) and reducing sedentarism in children and adolescents to offer significant health benefits and mitigate health risks. Physical fitness and sports practice seem to improve oxidative stress (OS) status during childhood. However, to our knowledge, there are no data regarding the influence of objectively-measured physical activity (PA) and sedentarism on OS status in children and adolescents. The present study aimed to evaluate the influence of moderate and vigorous PA and sedentarism on OS and plasma total antioxidant capacity (TAC) in a selected Spanish population of 216 children and adolescents from the GENOBOX study. PA (light, moderate, and vigorous) and sedentarism (i.e., sedentary time (ST)) were measured by accelerometry. A Physical Activity-Sedentarism Score (PASS) was developed integrating moderate and vigorous PA and ST levels. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and isoprostane F2α (F2-IsoPs), as markers of OS, were determined by ELISA; and TAC was estimated by colorimetry using an antioxidant kit. A higher PASS was associated with lower plasma TAC and urinary 8-OHdG and F2-IsoPs, showing a better redox profile. Reduced OS markers (8-OHdG and F2-IsoPs) in children with higher PASS may diminish the need of maintaining high concentrations of antioxidants in plasma during rest to achieve redox homeostasis.es_ES
dc.description.versionYeses_ES
dc.identifier.citationLlorente-Cantarero FJ, Aguilar-Gomez FJ, Leis R, Bueno G, Ruperez AI, Anguita-Ruiz A, et al. Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study. Antioxidants. 2021;10(2):320es_ES
dc.identifier.doi10.3390/antiox10020320es_ES
dc.identifier.essn2076-3921
dc.identifier.pmcPMC7924393
dc.identifier.pmid33672676es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3506
dc.journal.titleAntioxidants
dc.language.isoen
dc.page.number14 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/10/2/320es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPhysical activityes_ES
dc.subjectAccelerometryes_ES
dc.subjectOxidative stresses_ES
dc.subjectPlasma total antioxidant capacityes_ES
dc.subject8-hydroxy-2′-deoxyguanosinees_ES
dc.subjectIsoprostane F2αes_ES
dc.subjectEjercicio físicoes_ES
dc.subjectAcelerometríaes_ES
dc.subjectEstrés oxidativoes_ES
dc.subject8-Hidroxi-2'-Desoxicoguanosinaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Antioxidantses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Titrimetry::Colorimetryes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Physical Fitnesses_ES
dc.subject.meshMedical Subject Headings::Health Care::Health Care Economics and Organizations::Organizations::International Agencies::United Nations::World Health Organizationes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stresses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunoassay::Immunoenzyme Techniques::Enzyme-Linked Immunosorbent Assayes_ES
dc.titleRelationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Studyes_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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