Publication:
Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.

dc.contributor.authorMorón-Calvente, Virginia
dc.contributor.authorRomero-Pinedo, Salvador
dc.contributor.authorToribio-Castelló, Sofía
dc.contributor.authorPlaza-Díaz, Julio
dc.contributor.authorAbadía-Molina, Ana C
dc.contributor.authorRojas-Barros, Domingo I
dc.contributor.authorBeug, Shawn T
dc.contributor.authorLaCasse, Eric C
dc.contributor.authorMacKenzie, Alex
dc.contributor.authorKorneluk, Robert
dc.contributor.authorAbadía-Molina, Francisco
dc.date.accessioned2023-01-25T10:04:51Z
dc.date.available2023-01-25T10:04:51Z
dc.date.issued2018-03-08
dc.description.abstractMonocytes and macrophages constitute the first line of defense of the immune system against external pathogens. Macrophages have a highly plastic phenotype depending on environmental conditions; the extremes of this phenotypic spectrum are a pro-inflammatory defensive role (M1 phenotype) and an anti-inflammatory tissue-repair one (M2 phenotype). The Inhibitor of Apoptosis (IAP) proteins have important roles in the regulation of several cellular processes, including innate and adaptive immunity. In this study we have analyzed the differential expression of the IAPs, NAIP, cIAP1 and cIAP2, during macrophage differentiation and polarization into M1 or M2. In polarized THP-1 cells and primary human macrophages, NAIP is abundantly expressed in M2 macrophages, while cIAP1 and cIAP2 show an inverse pattern of expression in polarized macrophages, with elevated expression levels of cIAP1 in M2 and cIAP2 preferentially expressed in M1. Interestingly, treatment with the IAP antagonist SMC-LCL161, induced the upregulation of NAIP in M2, the downregulation of cIAP1 in M1 and M2 and an induction of cIAP2 in M1 macrophages.
dc.identifier.doi10.1371/journal.pone.0193643
dc.identifier.essn1932-6203
dc.identifier.pmcPMC5843221
dc.identifier.pmid29518103
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843221/pdf
dc.identifier.unpaywallURLhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0193643&type=printable
dc.identifier.urihttp://hdl.handle.net/10668/12219
dc.issue.number3
dc.journal.titlePloS one
dc.journal.titleabbreviationPLoS One
dc.language.isoen
dc.organizationIBS
dc.page.numbere0193643
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshApoptosis Regulatory Proteins
dc.subject.meshBaculoviral IAP Repeat-Containing 3 Protein
dc.subject.meshBlotting, Western
dc.subject.meshCell Differentiation
dc.subject.meshCells, Cultured
dc.subject.meshFlow Cytometry
dc.subject.meshGene Expression
dc.subject.meshGene Expression Profiling
dc.subject.meshHumans
dc.subject.meshInhibitor of Apoptosis Proteins
dc.subject.meshIntracellular Signaling Peptides and Proteins
dc.subject.meshMacrophages
dc.subject.meshMitochondrial Proteins
dc.subject.meshMonocytes
dc.subject.meshNeuronal Apoptosis-Inhibitory Protein
dc.subject.meshRNA, Messenger
dc.subject.meshUbiquitin-Protein Ligases
dc.titleInhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number13
dspace.entity.typePublication

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