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Microglia: Agents of the CNS Pro-Inflammatory Response

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dc.contributor.authorRodríguez-Gómez, José A.
dc.contributor.authorKavanagh, Edel
dc.contributor.authorEngskog-Vlachos, Pinelopi
dc.contributor.authorEngskog, Mikael K. R.
dc.contributor.authorHerrera, Antonio J.
dc.contributor.authorEspinosa-Oliva, Ana M.
dc.contributor.authorJoseph, Bertrand
dc.contributor.authorHajji, Nabil
dc.contributor.authorVenero, José L.
dc.contributor.authorBurguillos, Miguel A.
dc.contributor.authoraffiliation[Rodríguez-Gómez,JA; Herrera,AJ; Espinosa-Oliva,AM; Venero,JL; Burguillos,MA] Institute of Biomedicine of Seville (IBIS)-Hospital Universitario Virgen del Rocío/CSIC/University of Seville, Seville, Spain. [Rodríguez-Gómez,JA] Department of Medical Physiology and Biophysics, Faculty of Medicine, University of Seville, Sevilla, Spain. [Kavanagh,E; Herrera,AJ; Espinosa-Oliva,AM; Venero,JL; Burguillos,MA] Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Seville, Seville, Spain. [Engskog-Vlachos,P; Joseph,B] Institute of Environmental Medicine, Toxicology Unit, Karolinska Institute, Stockholm, Sweden. [Engskog,MKR] Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden. [Hajji,N] Division of Brain Sciences, The John Fulcher Molecular Neuro-Oncology Laboratory, Imperial College London, London, UK.
dc.contributor.funderThis review was funded by the Spanish Ministerio de Ciencia, Innovación y Universidades /FEDER/UE RTI2018-098645-B-100, FEDER I+D+i-USE US-1265062 and US-1264806, the Swedish Brain Foundation and Brain Tumour Research Campaign (BTRC), and Brain Tumour Research (BTR). M.A.B. was funded by the Spanish Ministerio de Economia y Competitividad (Programa Ramón y Cajal: RYC-2017-21804).
dc.date.accessioned2022-04-28T11:59:36Z
dc.date.available2022-04-28T11:59:36Z
dc.date.issued2020-07-17
dc.description.abstractThe pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research of microglia spans over a century, the last two decades have increased our understanding exponentially. Here, we discuss the phenotypic transformation from homeostatic microglia towards reactive microglia, initiated by specific ligand binding to pattern recognition receptors including toll-like receptor-4 (TLR4) or triggering receptors expressed on myeloid cells-2 (TREM2), as well as pro-inflammatory signaling pathways triggered such as the caspase-mediated immune response. Additionally, new research disciplines such as epigenetics and immunometabolism have provided us with a more holistic view of how changes in DNA methylation, microRNAs, and the metabolome may influence the pro-inflammatory response. This review aimed to discuss our current knowledge of pro-inflammatory microglia from different angles, including recent research highlights such as the role of exosomes in spreading neuroinflammation and emerging techniques in microglia research including positron emission tomography (PET) scanning and the use of human microglia generated from induced pluripotent stem cells (iPSCs). Finally, we also discuss current thoughts on the impact of pro-inflammatory microglia in neurodegenerative diseases.es_ES
dc.description.versionYeses_ES
dc.identifier.citationRodríguez-Gómez JA, Kavanagh E, Engskog-Vlachos P, Engskog MKR, Herrera AJ, Espinosa-Oliva AM, et al. Microglia: Agents of the CNS Pro-Inflammatory Response. Cells. 2020 Jul 17;9(7):1717es_ES
dc.identifier.doi10.3390/cells9071717es_ES
dc.identifier.essn2073-4409
dc.identifier.pmcPMC7407646
dc.identifier.pmid32709045es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3592
dc.journal.titleCells
dc.language.isoen
dc.page.number46 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2073-4409/9/7/1717/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMicrogliaes_ES
dc.subjectInflammationes_ES
dc.subjectTLR4es_ES
dc.subjectTREM2es_ES
dc.subjectCaspaseses_ES
dc.subjectEpigeneticses_ES
dc.subjectmetabolomicses_ES
dc.subjectiPSCses_ES
dc.subjectMicroglíaes_ES
dc.subjectInflamaciónes_ES
dc.subjectReceptor Toll-Like 4es_ES
dc.subjectCaspasases_ES
dc.subjectEpigenómicaes_ES
dc.subjectMetabolómicaes_ES
dc.subjectCélulas madre pluripotentes inducidases_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Apoptosis Regulatory Proteins::Caspaseses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous Systemes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetices_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Neuroglia::Microgliaes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Biologicales_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cells::Pluripotent Stem Cells::Induced Pluripotent Stem Cellses_ES
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Epigenomicses_ES
dc.titleMicroglia: Agents of the CNS Pro-Inflammatory Responsees_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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