Publication:
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.

Simple item page
dc.contributor.authorCostela-Ruiz, Víctor J
dc.contributor.authorIllescas-Montes, Rebeca
dc.contributor.authorPuerta-Puerta, Jose M
dc.contributor.authorRuiz, Concepción
dc.contributor.authorMelguizo-Rodríguez, Lucia
dc.date.accessioned2023-02-09T09:35:29Z
dc.date.available2023-02-09T09:35:29Z
dc.date.issued2020-06-02
dc.description.abstractCOVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.
dc.identifier.doi10.1016/j.cytogfr.2020.06.001
dc.identifier.essn1879-0305
dc.identifier.pmcPMC7265853
dc.identifier.pmid32513566
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265853/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.cytogfr.2020.06.001
dc.identifier.urihttp://hdl.handle.net/10668/15704
dc.journal.titleCytokine & growth factor reviews
dc.journal.titleabbreviationCytokine Growth Factor Rev
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.page.number62-75
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.rights.accessRightsopen access
dc.subjectCOVID-19
dc.subjectChemokines
dc.subjectCytokine storm
dc.subjectGrowth factors
dc.subjectSARS-CoV-2
dc.subject.meshBetacoronavirus
dc.subject.meshCOVID-19
dc.subject.meshCoronavirus Infections
dc.subject.meshCytokine Release Syndrome
dc.subject.meshCytokines
dc.subject.meshHumans
dc.subject.meshPandemics
dc.subject.meshPneumonia, Viral
dc.subject.meshSARS-CoV-2
dc.subject.meshSignal Transduction
dc.titleSARS-CoV-2 infection: The role of cytokines in COVID-19 disease.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number54
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
PMC7265853.pdf
Size:
1.63 MB
Format:
Adobe Portable Document Format
Download

Collections

SAS - Hospital Universitario Virgen de las Nieves

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía