Publication: [Treatment adherence with levetiracetam: a non-interventionist retrospective observation-based study].
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Date
2016
Authors
Serrano-Castro, P J
Mauri-Llerda, J A
Garcia, A
Rocamora, R
Pardo-Merino, A
Garcia-Garcia, P
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Abstract
Treatment adherence is a factor that is affecting the effectiveness of antiepileptic drugs. Levetiracetam is a drug whose effectiveness and safety is well established and is available in different oral formulations (granulates in sachets, tablets, oral solution), but information on treatment adherence/compliance with these oral formulations is limited. To determine treatment adherence with levetiracetam formulations (granulates in sachets, tablets) in adult and elderly people. Retrospective observational non-interventionist study. During the three months before the study patients should be treated with levetiracetam (granulates in sachets or tablets), either alone or in combination. Compliance tests (Green-Morisky modified test) as well as a satisfaction questionnaire investigator and patient/caregiver is assessed. Data were analyzed using SPSS v. 21.0 program. A total of 466 patients completed the study. The average age was 52.75 ± 19.17 years old and the average over 65 years of 72.79 ± 6.15. 55.4% were men. Compliance is related to the variable 'pharmaceutical formulation' and with age (p = 0.031). The risk of non-compliance was 86.4% higher among those taking tablets versus granulates in sachets of levetiracetam (odds ratio: 1.864). Likewise, the non-compliance was greater among patients over 65 years. The non-compliance was related to attributing of memory failures. Patients older are more difficult to compliance. The granulates levetiracetam in sachets improves compliance.
Description
MeSH Terms
Adult
Aged
Anticonvulsants
Female
Humans
Levetiracetam
Male
Medication Adherence
Middle Aged
Piracetam
Retrospective Studies
Aged
Anticonvulsants
Female
Humans
Levetiracetam
Male
Medication Adherence
Middle Aged
Piracetam
Retrospective Studies