Publication: Effects of combined D-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet.
dc.contributor.author | Hereu, Mercè | |
dc.contributor.author | Ramos-Romero, Sara | |
dc.contributor.author | Busquets, Cristina | |
dc.contributor.author | Atienza, Lidia | |
dc.contributor.author | Amézqueta, Susana | |
dc.contributor.author | Miralles-Pérez, Bernat | |
dc.contributor.author | Nogués, Maria Rosa | |
dc.contributor.author | Méndez, Lucía | |
dc.contributor.author | Medina, Isabel | |
dc.contributor.author | Torres, Josep Lluís | |
dc.date.accessioned | 2023-02-08T14:37:26Z | |
dc.date.available | 2023-02-08T14:37:26Z | |
dc.date.issued | 2019-11-12 | |
dc.description.abstract | Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of D-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with D-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with D-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of D-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of D-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs. | |
dc.identifier.doi | 10.1038/s41598-019-52678-5 | |
dc.identifier.essn | 2045-2322 | |
dc.identifier.pmc | PMC6851385 | |
dc.identifier.pmid | 31719544 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851385/pdf | |
dc.identifier.unpaywallURL | https://www.nature.com/articles/s41598-019-52678-5.pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/14681 | |
dc.issue.number | 1 | |
dc.journal.title | Scientific reports | |
dc.journal.titleabbreviation | Sci Rep | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Puerta del Mar | |
dc.page.number | 16628 | |
dc.pubmedtype | Journal Article | |
dc.pubmedtype | Research Support, Non-U.S. Gov't | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Blood Glucose | |
dc.subject.mesh | Diet, High-Fat | |
dc.subject.mesh | Drug Therapy, Combination | |
dc.subject.mesh | Fatty Acids, Omega-3 | |
dc.subject.mesh | Gastrointestinal Microbiome | |
dc.subject.mesh | Glucose Tolerance Test | |
dc.subject.mesh | Imino Pyranoses | |
dc.subject.mesh | Insulin | |
dc.subject.mesh | Leptin | |
dc.subject.mesh | Male | |
dc.subject.mesh | Prediabetic State | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, Sprague-Dawley | |
dc.subject.mesh | Risk Factors | |
dc.title | Effects of combined D-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 9 | |
dspace.entity.type | Publication |
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