Publication:
Effects of combined D-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet.

dc.contributor.authorHereu, Mercè
dc.contributor.authorRamos-Romero, Sara
dc.contributor.authorBusquets, Cristina
dc.contributor.authorAtienza, Lidia
dc.contributor.authorAmézqueta, Susana
dc.contributor.authorMiralles-Pérez, Bernat
dc.contributor.authorNogués, Maria Rosa
dc.contributor.authorMéndez, Lucía
dc.contributor.authorMedina, Isabel
dc.contributor.authorTorres, Josep Lluís
dc.date.accessioned2023-02-08T14:37:26Z
dc.date.available2023-02-08T14:37:26Z
dc.date.issued2019-11-12
dc.description.abstractFood contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of D-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with D-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with D-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of D-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of D-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs.
dc.identifier.doi10.1038/s41598-019-52678-5
dc.identifier.essn2045-2322
dc.identifier.pmcPMC6851385
dc.identifier.pmid31719544
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851385/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41598-019-52678-5.pdf
dc.identifier.urihttp://hdl.handle.net/10668/14681
dc.issue.number1
dc.journal.titleScientific reports
dc.journal.titleabbreviationSci Rep
dc.language.isoen
dc.organizationHospital Universitario Puerta del Mar
dc.page.number16628
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAnimals
dc.subject.meshBlood Glucose
dc.subject.meshDiet, High-Fat
dc.subject.meshDrug Therapy, Combination
dc.subject.meshFatty Acids, Omega-3
dc.subject.meshGastrointestinal Microbiome
dc.subject.meshGlucose Tolerance Test
dc.subject.meshImino Pyranoses
dc.subject.meshInsulin
dc.subject.meshLeptin
dc.subject.meshMale
dc.subject.meshPrediabetic State
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshRisk Factors
dc.titleEffects of combined D-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

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