Publication: The human bone marrow harbors a CD45- CD11B+ cell progenitor permitting rapid microglia-like cell derivative approaches.
dc.contributor.author | Bruzelius, Andreas | |
dc.contributor.author | Hidalgo, Isabel | |
dc.contributor.author | Boza-Serrano, Antonio | |
dc.contributor.author | Hjelmér, Anna-Giorgia | |
dc.contributor.author | Tison, Amelie | |
dc.contributor.author | Deierborg, Tomas | |
dc.contributor.author | Bengzon, Johan | |
dc.contributor.author | Ramos-Moreno, Tania | |
dc.date.accessioned | 2023-02-09T10:38:09Z | |
dc.date.available | 2023-02-09T10:38:09Z | |
dc.date.issued | 2020-12-09 | |
dc.description.abstract | Microglia, the immune sentinel of the central nervous system (CNS), are generated from yolk sac erythromyeloid progenitors that populate the developing CNS. Interestingly, a specific type of bone marrow-derived monocyte is able to express a yolk sac microglial signature and populate CNS in disease. Here we have examined human bone marrow (hBM) in an attempt to identify novel cell sources for generating microglia-like cells to use in cell-based therapies and in vitro modeling. We demonstrate that hBM stroma harbors a progenitor cell that we name stromal microglial progenitor (STR-MP). STR-MP single-cell gene analysis revealed the expression of the consensus genetic microglial signature and microglial-specific genes present in development and CNS pathologies. STR-MPs can be expanded and generate microglia-like cells in vitro, which we name stromal microglia (STR-M). STR-M cells show phagocytic ability, classically activate, and survive and phagocyte in human brain tissue. Thus, our results reveal that hBM harbors a source of microglia-like precursors that can be used in patient-centered fast derivative approaches. | |
dc.identifier.doi | 10.1002/sctm.20-0127 | |
dc.identifier.essn | 2157-6580 | |
dc.identifier.pmc | PMC7980218 | |
dc.identifier.pmid | 33295698 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980218/pdf | |
dc.identifier.unpaywallURL | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sctm.20-0127 | |
dc.identifier.uri | http://hdl.handle.net/10668/16762 | |
dc.issue.number | 4 | |
dc.journal.title | Stem cells translational medicine | |
dc.journal.titleabbreviation | Stem Cells Transl Med | |
dc.language.iso | en | |
dc.organization | Instituto de Biomedicina de Sevilla-IBIS | |
dc.organization | Hospital Universitario Virgen del Rocío | |
dc.page.number | 582-597 | |
dc.pubmedtype | Journal Article | |
dc.pubmedtype | Research Support, Non-U.S. Gov't | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | bone marrow | |
dc.subject | common myeloid progenitor | |
dc.subject | human bone marrow | |
dc.subject | microglia | |
dc.subject | microglia-like cell in vitro model | |
dc.subject | microglial precursor | |
dc.subject | pluripotent stem cell | |
dc.subject | primitive myeloid progenitor | |
dc.subject.mesh | Bone Marrow | |
dc.subject.mesh | CD11b Antigen | |
dc.subject.mesh | Central Nervous System | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Leukocyte Common Antigens | |
dc.subject.mesh | Microglia | |
dc.subject.mesh | Stem Cells | |
dc.title | The human bone marrow harbors a CD45- CD11B+ cell progenitor permitting rapid microglia-like cell derivative approaches. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 10 | |
dspace.entity.type | Publication |
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