Publication:
Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

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dc.contributor.authorRomero, Alejandro
dc.contributor.authorRamos, Eva
dc.contributor.authorPatiño, Paloma
dc.contributor.authorOset-Gasque, Maria J
dc.contributor.authorLopez-Muñoz, Francisco
dc.contributor.authorMarco-Contelles, Jose
dc.contributor.authorAyuso, María I
dc.contributor.authorAlcazar, Alberto
dc.date.accessioned2023-01-25T09:46:52Z
dc.date.available2023-01-25T09:46:52Z
dc.date.issued2016-11-23
dc.description.abstractStroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies . Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power . In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented.
dc.description.versionSi
dc.identifier.citationRomero A, Ramos E, Patiño P, Oset-Gasque MJ, López-Muñoz F, Marco-Contelles J, et al. Melatonin and Nitrones As Potential Therapeutic Agents for Stroke. Front Aging Neurosci. 2016 Nov 23;8:281.
dc.identifier.doi10.3389/fnagi.2016.00281
dc.identifier.issn1663-4365
dc.identifier.pmcPMC5120103
dc.identifier.pmid 27932976
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120103/pdf
dc.identifier.unpaywallURLhttps://www.frontiersin.org/articles/10.3389/fnagi.2016.00281/pdf
dc.identifier.urihttp://hdl.handle.net/10668/11259
dc.journal.titleFrontiers in aging neuroscience
dc.journal.titleabbreviationFront Aging Neurosci
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number7
dc.provenanceRealizada la curación de contenido 22/05/2025.
dc.publisherFrontiers Research Foundation
dc.pubmedtyperesearch article
dc.relation.publisherversionhttps://doi.org/10.3389/fnagi.2016.00281
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectmelatonin
dc.subjectneuroprotection
dc.subjectnitrones
dc.subjectoxidative stress
dc.subjectstroke
dc.subject.decsTerapéutica
dc.subject.decsMelatonina
dc.subject.decsEnfermedad
dc.subject.decsAntioxidantes
dc.subject.decsRadicales Libres
dc.subject.decsEnvejecimiento
dc.subject.decsNeuroprotección
dc.subject.meshTissue Plasminogen Activator
dc.subject.meshAntioxidants
dc.subject.meshMelatonin
dc.subject.meshnitrones
dc.subject.meshNeuroprotection
dc.subject.meshStroke
dc.subject.meshAging
dc.subject.meshFree Radicals
dc.titleMelatonin and Nitrones As Potential Therapeutic Agents for Stroke.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number8
dspace.entity.typePublication

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