Publication:
Vaginal progesterone as maintenance treatment after an episode of preterm labour (PROMISE) study: a multicentre, double-blind, randomised, placebo-controlled trial.

dc.contributor.authorPalacio, M
dc.contributor.authorCobo, T
dc.contributor.authorAntolín, E
dc.contributor.authorRamirez, M
dc.contributor.authorCabrera, F
dc.contributor.authorMozo de Rosales, F
dc.contributor.authorBartha, J L
dc.contributor.authorJuan, M
dc.contributor.authorMartí, A
dc.contributor.authorOros, D
dc.contributor.authorRodríguez, À
dc.contributor.authorScazzocchio, E
dc.contributor.authorOlivares, J M
dc.contributor.authorVarea, S
dc.contributor.authorRíos, J
dc.contributor.authorGratacós, E
dc.contributor.authorPROMISE Collaborative Group
dc.date.accessioned2023-01-25T08:31:33Z
dc.date.available2023-01-25T08:31:33Z
dc.date.issued2016-03-30
dc.description.abstractTo evaluate whether maintenance treatment with vaginal progesterone after an arrested preterm labour reduces the incidence of preterm delivery. Multicentre, randomised, double-blind, placebo-controlled trial. Twelve tertiary care centres in Spain. A total of 265 women with singleton pregnancy, preterm labour successfully arrested with tocolytic treatment, and cervical length of Randomisation was stratified by gestational age (from 24.0 to Primary outcome was delivery before 34.0 and 37.0 weeks of gestation. Secondary outcomes were discharge-to-delivery time, readmissions because of preterm labour, emergency service use, and neonatal morbidity and mortality. From June 2008 through June 2012, 1419 women were screened: 472 met the inclusion criteria and 265 were randomised. The final analysis included 258 women: 126 in the progesterone group and 132 in the placebo group. There were no significant differences between the progesterone and placebo groups in terms of delivery at A maintenance treatment of 200 mg of daily vaginal progesterone capsules in women discharged home after an episode of arrested preterm labour did not significantly reduce the rate of preterm delivery. Maintenance progesterone in 258 women after arrested PTL showed no benefit.
dc.identifier.doi10.1111/1471-0528.13956
dc.identifier.essn1471-0528
dc.identifier.pmid27028759
dc.identifier.unpaywallURLhttps://obgyn.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1471-0528.13956
dc.identifier.urihttp://hdl.handle.net/10668/9955
dc.issue.number12
dc.journal.titleBJOG : an international journal of obstetrics and gynaecology
dc.journal.titleabbreviationBJOG
dc.language.isoen
dc.organizationHospital Universitario Puerta del Mar
dc.organizationHospital Universitario Virgen Macarena
dc.page.number1990-1999
dc.pubmedtypeJournal Article
dc.pubmedtypeComment
dc.rights.accessRightsopen access
dc.subjectMaintenance treatment
dc.subjectpreterm labour
dc.subjectprogesterone
dc.subject.meshDouble-Blind Method
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant, Newborn
dc.subject.meshObstetric Labor, Premature
dc.subject.meshPremature Birth
dc.subject.meshProgesterone
dc.subject.meshVagina
dc.titleVaginal progesterone as maintenance treatment after an episode of preterm labour (PROMISE) study: a multicentre, double-blind, randomised, placebo-controlled trial.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number123
dspace.entity.typePublication

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