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Generation of a H9 Clonal Cell Line With Inducible Expression of NUP98-KDM5A Fusion Gene in the AAVS1 Safe Harbor Locus.

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dc.contributor.authorDomingo-Reines, Joan
dc.contributor.authorMartinez-Navajas, Gonzalo
dc.contributor.authorMontes, Rosa
dc.contributor.authorLamolda, Mar
dc.contributor.authorSimon, Iris
dc.contributor.authorCastaño, Julio
dc.contributor.authorRios-Pelegrina, Rosa
dc.contributor.authorLopez-Hidalgo, Javier Luis
dc.contributor.authorGarcia Del Moral, Raimundo
dc.contributor.authorMarchal, Juan A
dc.contributor.authorReal, Pedro J
dc.contributor.authorRamos-Mejia, Veronica
dc.contributor.funderHealth Institute Carlos III
dc.contributor.funderAsociación de Madres y Padres de Niños Oncológicos de Granada (AUPA)
dc.contributor.funderAsociación El Mundo de Namu
dc.contributor.funderGrupo Girasoles de Alhaurín de la Torre,
dc.contributor.funderMinistry of Science and Innovatio
dc.contributor.funderRamon y Cajal program
dc.contributor.funderMinistry of Economy and Competitiveness
dc.contributor.funderFundacion Publica Andaluza Progreso y Salud (FPS)
dc.date.accessioned2023-05-03T13:39:11Z
dc.date.available2023-05-03T13:39:11Z
dc.date.issued2022-05-12
dc.description.abstractPediatric acute myeloid leukemia (AML) is a rare and heterogeneous disease that remains the major cause of mortality in children with leukemia. To improve the outcome of pediatric AML we need to gain knowledge on the biological bases of this disease. NUP98-KDM5A (NK5A) fusion protein is present in a particular subgroup of young pediatric patients with poor outcome. We report the generation and characterization of human Embryonic Stem Cell (hESC) clonal lines with inducible expression of NK5A. Temporal control of NK5A expression during hematopoietic differentiation from hESC will be critical for elucidating its participation during the leukemogenic process.
dc.description.versionSi
dc.identifier.citationDomingo-Reinés J, Martínez-Navajas G, Montes R, Lamolda M, Simón I, Castaño J, et al. Generation of a H9 Clonal Cell Line With Inducible Expression of NUP98-KDM5A Fusion Gene in the AAVS1 Safe Harbor Locus. Front Cell Dev Biol. 2022 Jun 1;10:846092.
dc.identifier.doi10.3389/fcell.2022.846092
dc.identifier.issn2296-634X
dc.identifier.pmcPMC9200071
dc.identifier.pmid35721502
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200071/pdf
dc.identifier.unpaywallURLhttps://www.frontiersin.org/articles/10.3389/fcell.2022.846092/pdf
dc.identifier.urihttp://hdl.handle.net/10668/20532
dc.journal.titleFrontiers in cell and developmental biology
dc.journal.titleabbreviationFront Cell Dev Biol
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number8
dc.publisherFrontiers Research Foundation
dc.pubmedtypeJournal Article
dc.relation.projectIDRYC-2015-18382
dc.relation.projectID(F17/00178
dc.relation.publisherversionhttps://doi.org/10.3389/fcell.2022.846092
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectacute myeliod leukemia
dc.subjectdisease model
dc.subjecthematopoieisis
dc.subjecthuman stem cell
dc.subjectpediatric
dc.subject.decsCélulas madre embrionarias
dc.subject.decsHumanas
dc.subject.decsHumanos
dc.subject.decsLeucemia mieloide aguda
dc.subject.decsNiño
dc.subject.decsPoro nuclear
dc.subject.decsProteínas
dc.subject.meshHumans
dc.subject.meshChild
dc.subject.meshnuclear pore complex protein 98
dc.subject.meshHuman Embryonic Stem Cells
dc.subject.meshLeukemia, Myeloid, Acute
dc.titleGeneration of a H9 Clonal Cell Line With Inducible Expression of NUP98-KDM5A Fusion Gene in the AAVS1 Safe Harbor Locus.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication

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