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Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms

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dc.contributor.authorCruz-Merino, Luis de la
dc.contributor.authorHenao Carrasco, Fernando
dc.contributor.authorVicente Baz, David
dc.contributor.authorNogales Fernández, Esteban
dc.contributor.authorReina Zoilo, Juan José
dc.contributor.authorCodes Manuel de Villena, Manuel
dc.contributor.authorGrande Pulido, Enrique
dc.contributor.authoraffiliation[Cruz-Merino, L de la ; Henao Carrasco, F; Vicente Baz, D; Nogales Fernández, E; Reina Zoilo, JJ; Codes Manuel de Villena, M] Clinical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Grande Pulido, E] Clinical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.es
dc.date.accessioned2013-06-05T10:39:15Z
dc.date.available2013-06-05T10:39:15Z
dc.date.issued2011
dc.descriptionJournal Article; Review;es
dc.description.abstractImpact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells.es
dc.description.versionYeses
dc.identifier.citationCruz-Merino L de la, Henao Carrasco F, Vicente Baz D, Nogales Fernández E, Reina Zoilo JJ, Codes Manuel de Villena M, et al. Immune microenvironment in colorectal cancer: a new hallmark to change old paradigms. Clin. Dev. Immunol.; 2011:174149es
dc.identifier.doi10.1155/2011/174149
dc.identifier.essn1740-2530
dc.identifier.issn1740-2522
dc.identifier.pmcPMC3226426
dc.identifier.pmid22162710
dc.identifier.urihttp://hdl.handle.net/10668/1098
dc.journal.titleClinical & developmental immunology
dc.language.isoen
dc.publisherHindawi Publishing Corporationes
dc.relation.publisherversionhttp://www.hindawi.com/journals/cdi/2011/174149/abs/es
dc.rights.accessRightsopen access
dc.subjectAntígenos CD80es
dc.subjectAntineoplásicoses
dc.subjectAntígeno CTLA-4es
dc.subjectNeoplasias Colorrectaleses
dc.subjectPronósticoes
dc.subjectLinfocitos T Reguladoreses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::B7 Antigens::Antigens, CD80es
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agentses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Costimulatory and Inhibitory T-Cell Receptors::CTLA-4 Antigenes
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinomaes
dc.subject.meshMedical Subject Headings::Diseases::Digestive System Diseases::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasmses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocytes, Tumor-Infiltratinges
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Genomic Instability::Microsatellite Instabilityes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosises
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Cytokine-Induced Killer Cells::T-Lymphocytes, Cytotoxices
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocyte Subsets::T-Lymphocyte Subsets::T-Lymphocytes, Regulatoryes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Tumor Markers, Biologicales
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironmentes
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Antigen-Presenting Cellses
dc.titleImmune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigmses
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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