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Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients.

dc.contributor.authorRiccio, Maria E
dc.contributor.authorVerschuuren, Tess
dc.contributor.authorConzelmann, Nadine
dc.contributor.authorMartak, Daniel
dc.contributor.authorMeunier, Alexandre
dc.contributor.authorSalamanca, Elena
dc.contributor.authorDelgado, Mercedes
dc.contributor.authorGuther, Julia
dc.contributor.authorPeter, Silke
dc.contributor.authorPaganini, Julian
dc.contributor.authorMartischang, Romain
dc.contributor.authorSauser, Julien
dc.contributor.authorde-Kraker, Marlieke E A
dc.contributor.authorCherkaoui, Abdessalam
dc.contributor.authorFluit, Ad C
dc.contributor.authorCooper, Ben S
dc.contributor.authorHocquet, Didier
dc.contributor.authorKluytmans, Jan A J W
dc.contributor.authorTacconelli, Evelina
dc.contributor.authorRodriguez-Baño, Jesus
dc.contributor.authorHarbarth, Stephan
dc.contributor.groupMODERN WP2 study group
dc.date.accessioned2023-02-09T10:39:26Z
dc.date.available2023-02-09T10:39:26Z
dc.date.issued2021-01-06
dc.description.abstractThis study aimed to determine rates and risk factors of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) acquisition and transmission within households after hospital discharge of an ESBL-PE-positive index patient. Two-year prospective cohort study in five European cities. Patients colonized with ESBL-producing Escherichia coli (ESBL-Ec) or Klebsiella pneumoniae (ESBL-Kp), and their household contacts were followed up for 4 months after hospital discharge of the index case. At each follow up, participants provided a faecal sample and personal information. ESBL-PE whole-genome sequences were compared using pairwise single nucleotide polymorphism-based analysis. We enrolled 71 index patients carrying ESBL-Ec (n = 45), ESBL-Kp (n = 20) or both (n = 6), and 102 household contacts. The incidence of any ESBL-PE acquisition among household members initially free of ESBL-PE was 1.9/100 participant-weeks at risk. Nineteen clonally related household transmissions occurred (case to contact: 13; contact to case: 6), with an overall rate of 1.18 transmissions/100 participant-weeks at risk. Most of the acquisition and transmission events occurred within the first 2 months after discharge. The rate of ESBL-Kp household transmission (1.16/100 participant-weeks) was higher than of ESBL-Ec (0.93/100 participant-weeks), whereas more acquisitions were noted for ESBL-Ec (1.06/100 participant-weeks) compared with ESBL-Kp (0.65/100 participant-weeks). Providing assistance for urinary and faecal excretion to the index case by household members increased the risk of ESBL-PE transmission (adjusted prevalence ratio 4.3; 95% CI 1.3-14.1). ESBL-PE cases discharged from the hospital are an important source of ESBL-PE transmission within households. Most acquisition and transmission events occurred during the first 2 months after hospital discharge and were causally related to care activities at home, highlighting the importance of hygiene measures in community settings.
dc.description.versionSi
dc.identifier.citationRiccio ME, Verschuuren T, Conzelmann N, Martak D, Meunier A, Salamanca E, et al. Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients. Clin Microbiol Infect. 2021 Sep;27(9):1322-1329.
dc.identifier.doi10.1016/j.cmi.2020.12.024
dc.identifier.essn1469-0691
dc.identifier.pmid33421572
dc.identifier.unpaywallURLhttp://www.clinicalmicrobiologyandinfection.com/article/S1198743X20307849/pdf
dc.identifier.urihttp://hdl.handle.net/10668/16945
dc.issue.number9
dc.journal.titleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
dc.journal.titleabbreviationClin Microbiol Infect
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen Macarena
dc.page.number1322-1329
dc.provenanceRealizada la curación de contenido 28/05/2025.
dc.publisherElsevier Ltd
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://linkinghub.elsevier.com/retrieve/pii/S1198-743X(20)30784-9
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAcquisition
dc.subjectExtended-spectrum β-lactamase
dc.subjectHousehold
dc.subjectProspective cohort study
dc.subjectTransmission
dc.subject.decsHospitales
dc.subject.decsKlebsiella pneumoniae
dc.subject.decsIncidencia
dc.subject.decsFactores de riesgo
dc.subject.decsHigiene
dc.subject.decsEscherichia coli
dc.subject.meshEnterobacteriaceae Infections
dc.subject.meshEscherichia coli
dc.subject.meshFamily Characteristics
dc.subject.meshHospitals
dc.subject.meshHumans
dc.subject.meshKlebsiella pneumoniae
dc.subject.meshPatient Discharge
dc.subject.meshProspective Studies
dc.subject.meshRisk Factors
dc.subject.meshbeta-Lactamases
dc.titleHousehold acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number27
dspace.entity.typePublication

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